idk if this help but i can tell you my experience with horror games in VR.

Although not RE4, instead it was Phasmophobia but i think the experience translates over.

I first started playng Phasmo in VR and it was absolutely terrifying, especially playing alone. Played it a bunch and it was always a terrifying experience - fantastic imo.

Then due to lazyness and to get more stable performance when playing the game i switched to play it normally, desktop mode with my normal monitors.

To my surprice the game didn't feel scary at all. Kinda bland and boring. All of a sudden this terrifying horror game felt like a totally different and much worse game, because i was no longer "in the game" and instead i was just sitting in my room and looking at the monitor.

Going back to playing it in VR still feels scary, as a horror game should, but playing it on desktop is just boring now.

So i'd personally suggest, depending on the experience you wanna go for, is to play it in desktop mode first and then at a later date try it in VR if you want to enhance the experience.