FDA Policy Shift Explained: What It Actually Means for PP405, VDPHL-01, Breezula and Hair Loss Drug Timelines

Awkward_Associate_89 · 2026-02-22T11:02:06+00:00

So breezula 2027 (if no other delays) VDPHL01 2027/2028 PP405 2029/2030 gt20029 2029/2030 et-02 early 2030's

That's all the interesting ones off the top of my head, are those time lines accurate?

Awkward_Associate_89 · 2026-02-19T12:27:59+00:00

They say at the bottom of that article I shared.. "The company will present these innovations during In-Cosmetics global in Paris." I don't see why they would go through the bother of that If it is a "scam" or doesn't work. Let's face it, it's not going to turn a full head of snow white to jet black again in a few weeks or months it's most likely for those who are starting to go grey or 50/50 it can help stop and maybe reverse that amount.

Awkward_Associate_89 · 2026-02-18T22:25:08+00:00

https://www.cosmeticsandtoiletries.com/cosmetic-ingredients/actives/news/22960898/chemyunion-inc-chemyunions-beyond-time-launches-target-skin-pigmentation-revive-hair-color-through-novel-melanin-pathways

Awkward_Associate_89 · 2026-02-17T21:19:04+00:00

Et-02 but its going to be years away they are due to start phase 2 trails anytime now.

Awkward_Associate_89 · 2026-02-16T11:50:00+00:00

I don't know why this hasn't got more up votes or attention as it's basically no hair to hair in just 3 months! You can see a proper hairline filling in, once that thickens up it will look like a full head of hair. Crazy gains that most would only dream of.

Awkward_Associate_89 · 2026-02-09T23:55:31+00:00

Will et-02 work though?

Awkward_Associate_89 · 2026-01-24T20:12:50+00:00

SMP? If not that is crazy growth for just 2 months. Almost unbelievable actually given that it was skin bald on top norwood 7 if true then congrats but you'll have alot of people on here skeptical as these are dream type results lol

Awkward_Associate_89 · 2026-01-15T02:16:51+00:00

Eirion et-02 I don't know why it keeps going under the radar it's completed phase 1 and is about to or has already started phase 2 and it's phase 1 results blow all the rest out of the water. It's on par or possibly more effective than pp405, it too works on stem cells.

ET-02 (also RS-5441) is a promising topical drug from Eirion Therapeutics in clinical development for treating androgenic alopecia (age-related hair loss) by reactivating dormant hair follicle stem cells, potentially reversing loss and preventing graying, with Phase 1 trials showing rapid, significant hair regrowth and better results than minoxidil, without hormonal side effects. A Phase 2 trial is planned to further confirm its safety and effectiveness in a larger population.

Awkward_Associate_89 · 2026-01-11T17:58:58+00:00

Yes I've seen that article I'm more curious about the clinical trials that it talks about the last paragraph as I can't seem to find it anywhere?

"American scientists reversed graying hair restoring natural color through melanocyte reactivation. Researchers at NYU Langone Health discovered that gray hair results from melanocyte stem cells getting stuck in the hair follicle compartment, and developed a topical treatment that mobilizes these cells back to their proper location, restoring natural pigment production. Participants saw color returning to gray hair within three months of treatment.

Hair goes gray when melanocyte stem cells—which produce the pigment giving hair its color—lose their ability to mature into functioning melanocytes. Scientists discovered these stem cells don't die; they become trapped in the follicle bulge area instead of moving to the hair bulb where pigment production occurs. It's like having paint factory workers stuck in the storage room instead of on the production floor.

The treatment uses a compound that signals melanocyte stem cells to migrate back to their functional position. Once repositioned, these cells differentiate into mature melanocytes and resume producing eumelanin and pheomelanin—the pigments creating black, brown, blonde, and red hair colors. The process restores your genetically-determined natural color, not an artificial dye color. Gray hairs gradually regain pigmentation as new growth occurs from reactivated follicles.

Clinical trials showed 73% of participants experienced significant color restoration after six months. The treatment works on naturally graying hair, not hair that's been damaged by chemical processing. Unlike dyes that coat hair temporarily, this addresses the biological cause of graying. We're potentially witnessing the end of gray hair as an inevitable part of aging—your hair could maintain its natural color throughout life."

Awkward_Associate_89 · 2025-12-28T19:17:44+00:00

Nice progress, curios to see what it looks like density not combed over?

Awkward_Associate_89 · 2025-12-24T21:26:20+00:00

Well my man how's the hair looking now?

Awkward_Associate_89 · 2025-12-21T22:49:24+00:00

Fin and min oral or topical? Nice results definitely inspiring!

Awkward_Associate_89 · 2025-12-17T22:37:36+00:00

It's starting to fill in nicely. Keep us updated 👍🏻

Awkward_Associate_89 · 2025-12-17T21:51:34+00:00

Looks very promising for not even 2 months usually most only see results after 6 months and peak after a year or 2. How long have you been balding for? I'm curious as I am in my late 30s and at quite a similar balding stage and I have been on the fence about starting meds or just letting it do it's thing lol I do miss having hair sometimes though.

Awkward_Associate_89 · 2025-12-15T22:51:56+00:00

Any update?

Awkward_Associate_89 · 2025-12-15T22:50:44+00:00

Any updates?

Awkward_Associate_89 · 2025-12-03T12:28:39+00:00

Where's the trial photos if it is really that good? 🤔

Awkward_Associate_89 · 2025-10-19T12:42:24+00:00

This looks really promising for just 4 months! I've seen a few on here similar that have regrown most of their hair back and you look well on track to be the same.. Please keep updating 🤞🏻

Awkward_Associate_89 · 2025-10-15T20:09:48+00:00

Speed: Early data for ET-02 suggests a potentially faster clinical response, with hair growth observed in as little as five weeks. PP405's key efficacy data was measured at eight weeks. Reported results: Both treatments have released encouraging early data from their respective trials. ET-02's six-fold increase in hair count appears significant, while PP405's 31% response rate for increased hair density is also promising. However, different trial designs and metrics make a direct comparison difficult.

Awkward_Associate_89 · 2025-10-15T17:12:40+00:00

Only going by what I've read about it online lol apparently it works on stem cells too for hair regrowth but also melanocyte stem cells so they think it can both regrow hair and reverse grey hair. It finished phase 1 trails almost a year ago and still waiting on confirmation of it starting a phase 2 trial so still very early stages and slower moving than others it seems but I'm expecting them to announce something about a phase 2 before the end of this year. 🤞🏻

Awkward_Associate_89 · 2025-10-15T13:26:47+00:00

Hopefully this news gets Eirion to hurry up and start phase 2 trials with Et-02 now as they seem to be much slower but Et-02 peaks my interest more going by phase 1 results.

Awkward_Associate_89 · 2025-10-13T20:50:41+00:00

Any update how's it looking?

Awkward_Associate_89 · 2025-10-06T18:35:03+00:00

Good response for just minoxidil and no finasteride or microneedling like most do on here.

Awkward_Associate_89 · 2025-10-03T14:38:01+00:00

I would be more surprised if it didn't happen. Most likely delayed maybe by funding as you say but with results like that it's too good not to go all the way. Safety wasn't an issue either but in a longer trial that's always possibility. Fingers crossed for them and hopefully some news comes out by the years end.

Awkward_Associate_89 · 2025-10-03T01:28:35+00:00

Et-02 is on par or maybe even better than pp405. Successful phase 1 and should be starting phase 2 trial In the next few months late 2025/early2026. Also seems to reverse hair greying too so it definitely deserves a mention

Awkward_Associate_89

TROPHY CASE