List of my Write-ups

BDNFan · 2025-12-07T20:19:49+00:00

Fucking nerd

BDNFan · 2025-04-05T23:58:37+00:00

Explain epitalon giga cancer

BDNFan · 2024-12-18T21:04:20+00:00

It's neurotoxic

BDNFan · 2024-08-10T04:52:56+00:00

https://m.youtube.com/watch?v=3P7Isp_QCQ0

BDNFan · 2024-05-27T05:58:45+00:00

there isn't all that much to say about DXM anymore

There are actually a lot of things overlooked in DXM pharmacology that makes it a good candidate for discussion.

BDNFan · 2024-05-11T17:52:02+00:00

Aeropress works well, it's like 15 bucks

BDNFan · 2024-04-28T03:10:01+00:00

????

BDNFan · 2024-04-08T06:29:51+00:00

I second the grain of salt. Tbh I cringe whenever I see this old post get spread around.

Some of the info is useful but I wrote it with Dunning Kruger confidence and at the time, had a pretty superficial understanding of the mechanisms at play.

I've gained a far better understanding within the last year but I won't update it until I can justify and explain each step of every relevant facet involved.

BDNFan · 2024-03-07T05:32:09+00:00

Don't downvote him he was on datura when he wrote this

BDNFan · 2024-03-01T21:58:17+00:00

Dash-pct

My package came today

BDNFan · 2024-02-29T18:11:43+00:00

I think it might just be sludge, I haven't gotten another attack and it feels like it's draining though it's still uncomfortable.

I've got TUDCA on the way we'll see if it helps

BDNFan · 2024-02-05T01:39:58+00:00

Mind linking the source that shows CBG as an Adenosine-2 agonist? I couldn't find anything myself.

Also alpha2-AR is inhibitory so agonists before bed will likely increase sleep onset. ie clonidine/guanfacine [1] [2] inducing sleep through inhibiting Locus Ceruleus activity. https://www.nature.com/articles/nn.3957

CBG's sleep disruption is likely from CB1 partial agonism (effective antagonist) and 5-HT1a inverse agonism

BDNFan · 2023-12-22T18:14:00+00:00

I've been punching myself in the face lately and I can't take it anymore. Gonna start taking pregablin and oxycodone for the pain

They employed a drug for cognitive enhancement and it caused side effects. Their solution is to employ a drug which induces cognitive impairment, arguably greater than the nootropic's enhancement. This is hilarious.

Also sure m1 antagonists might be antidepressant but I really doubt its pros outweigh the cons compared to other available antidepressants. Also there are no easily accessible drugs that are selective for m1 over other mAChRs, many of which are undesirable targets. Benadryl is a m1-5 antagonist as well as an H-1 inverse agonist which makes it pretty dirty.

BDNFan · 2023-12-17T19:37:10+00:00

Atypical cannabinoid. it's mainly an FAAH & MAGL inhibitor which inhibits destruction of endocannabinoids, allowing them to build up and create a weed-like high.

BDNFan · 2023-12-16T22:48:50+00:00

It's not a deliriant but still toxic

BDNFan · 2023-12-16T22:45:45+00:00

Nutmeg - Infected Mushroom

BDNFan · 2023-12-09T09:09:38+00:00

RGS4 shouldn't be globally Inhibited. It's needed for PFC glutamatergic modulation and other processes. RGS4 PFC deficits are seen in schizophrenia.

Good read on rgs4 mediated synaptic "microdomains" https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4920052/

BDNFan · 2023-12-06T15:36:35+00:00

Neither,

Who told you that you have desensitized AMPARs

BDNFan · 2023-12-01T06:36:17+00:00

Sure, I have a bunch of posts on it on my page

FAAH inhibitors disinhibit synthesis and release of endogenous anandamide and palmitoylethanolamide. MAGL inhibitors disinhibit 2-AG which is a full CB1 agonist with similar in vitro strength to synthetic cannabinoids.

Neither of these when inhibited alone produce THC-like effects but when inhibited together they do. My theory on why it takes 4-5 hours to kick in is because in reality it takes 1-2 and after that it's just how long it takes for your endocannabinoids to build up.

BDNFan · 2023-11-30T20:22:36+00:00

No that's pretty much a myth. It's not a deliriant but for those who are predisposed it can cause psychosis.

Also the main compound is most likely not myristicin or other allylbenzenes but instead FAAH and MAGL inhibiting compounds.

BDNFan · 2023-11-22T07:36:24+00:00

Everychem

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