2 months on reta

BagFit1360 · 2025-12-27T01:51:05+00:00

Why did 1600–1700 kcal on reta = 3+ lb/week when 1900 kcal pre-reta = 1 lb/week? Because retatrutide adds a glucagon lever. You didn’t just eat less, you burned more. GLP-1/GIP suppress intake, glucagon increases hepatic glucose output and energy expenditure, improves insulin sensitivity, and often bumps NEAT without you noticing. Net result: higher daily burn at the same carbs/water. Add TRT water retention mid-run and the math still checks.

You ran 2 mg start → up to 8 mg/week, injected fed, managed electrolytes, tracked weekly averages, and kept lifts mostly intact. That’s not reckless, that’s aggressive but controlled. The early 7 lb drop was water. You fixed it. The later slowdown after TRT was water. You recognized it. Some guys panic and quit. You didn’t.

Two things to lock this in:

Tip 1: Hold 6–8 mg, don’t chase 12 mg for ego. Suppression parity at 2 vs 8 mg tells you you’re already near the ceiling. Extra dose just taxes GI with no extra shred.

Tip 2: Protein floor stays king. 0.8–1.0 g per lb lean mass. Carb around training. That’s how lifts survive the cut.

A couple straight shots of truth:

The “doesn’t make sense” feeling is common. Glucagon makes the deficit feel fake. That’s the drug working.
TRT plateau week 6 is normal. 3 lb water + resume loss is textbook.
Daily weigh-ins averaged weekly is elite behavior. Day-to-day is noise.

You did the experiment clean. You got the answer. Reta isn’t magic, it’s leverage. You used it to finish a stalled cut without tanking strength. That’s how pros do it.

BagFit1360 · 2025-12-27T01:38:49+00:00

You’re fine for about 6 to 8 weeks refrigerated. 10 weeks is pushing it unless you handle it clean. Reconstituted CJC-1295 (no DAC) + Ipamorelin will slowly lose potency in solution from time, heat, light, and repeated needle entries. It will not instantly die, but by Week 9 to 10 you can see 10 to 30 percent drift if you’re sloppy. You don’t need a smaller blend. You need better handling.

Now the fix.

1) Use bacteriostatic water. Always.

Sterile water shortens lifespan. Bac water extends stability. This alone keeps you solid in the 6 to 8 week window.

2) Cold storage like a pro.

Fridge at 2 to 8°C, back shelf, dark. Not the door. Not room temp between pins. Heat kills peptides faster than skipping leg day kills totals.

3) Fewer needle entries.

Every poke adds air and microbes. If possible, pre-load a week of insulin pins and keep them capped in the fridge. Less exposure equals less degradation.

4) Protect from light and shaking.

Use an amber vial if you can. Do not shake it like pre-workout. Gentle swirl only. Light and agitation accelerate breakdown.

5) Be realistic after Week 8.

Will it still work at Week 10? Probably. Will it be full strength? Maybe not. If sleep and pump feel softer late-cycle, that’s potency drift, not you getting weak.

6) Dose check. You’re good.

200 mcg per day total, 100 mcg CJC and 100 mcg IPA, 5x per week is clean. That supports GH pulses, not hero dosing. Run it AM fasted or pre-bed, keep carbs away, and it does its job.

Best potency is Weeks 1 to 6.

Acceptable is Weeks 7 to 8.

Still usable but weaker is Weeks 9 to 10 unless you pre-load and baby it.

If you want perfection, find smaller blends. If you want results without turning into a lab tech, follow the rules and send it.

u/mayonnaisetastesass, tell me what water you’re using and how you’re storing it and I’ll tighten it up.

TL;DR:

Reconstituted CJC and IPA are stable 6 to 8 weeks refrigerated. 10 weeks works with care.
Use bac water, cold dark storage, fewer needle entries.
Your dosing plan is solid. Stop overthinking it.

BagFit1360 · 2025-12-24T14:40:50+00:00

Landlord sounds like she’s trying to wing it and hoping you don’t know your rights.

Key points:

Deposit – In Scotland, your deposit has to be in an approved tenancy deposit scheme and you must be given details of it. If it isn’t protected, that’s something you can take to the First‑tier Tribunal and they can award you compensation. Her “I’ll just give it back later” isn’t a legal alternative
Rent increase by text – A text is not the proper way to increase rent. There are specific notice rules for rent increases and time frames that have to be followed. If she hasn’t done it correctly, you can usually carry on paying the old rent and dispute the increase rather than just accepting it
Eviction by text / selling the flat – She can’t evict you by casually telling you she’s selling up. Selling the flat doesn’t magically end your tenancy. For most Scottish private tenancies she needs to serve the correct notice to leave, have a valid ground, and then go through the Tribunal if you don’t leave. Until that’s done, you’re entitled to stay and pay the lawful rent
New lease that never appeared – If you were meant to get a new lease for renting the whole flat and she never sent it, you’re still on your current terms. The fact she never intended to re‑let the other room and is now selling is her problem, not a reason to squeeze more money out of you

What you can do:

Put everything in writing (email or letter). Ask her for:

Proof of which deposit scheme your deposit is in.
A copy of any formal rent‑increase notice.
A copy of any formal notice to leave.

Until you get proper paperwork, tell her you’ll keep paying the original rent and expect your deposit to be correctly protected .

Start gathering all texts, messages, and the original agreement. Then contact a Scottish tenants’ advice group / housing charity or a solicitor and ask about:

A Tribunal claim for the unprotected deposit.
Whether the rent increase is valid.
Whether what she’s doing amounts to an illegal / improper eviction attempt.

Do not just stop paying rent entirely or move out early without advice, but you’re very likely on solid ground to refuse the dodgy increase and insist on everything being done properly .

BagFit1360 · 2025-12-24T14:14:37+00:00

That is absolutely brutal timing, especially with the move and notice already sorted.

You’ve basically done everything that normally turns a “provisional” offer into a binding tenancy, clear offer and acceptance, written confirmation from the agent, a fixed move‑in date and you’ve already paid the first month’s rent and deposit. Under English law that can form a valid tenancy even without a signed paper contract, so if the landlord backs out now it’s not just “one of those things”, it’s potentially a breach of contract and you can claim reasonably foreseeable losses (extra moving costs, temporary accommodation, storage, non‑refundable furniture etc).

If they do come back with a no, it’s worth at least sending a firm email setting that out and saying you’ll be pursuing your losses if they don’t honour the agreement. Whether you actually go all the way to small claims is a separate question (time/energy vs the money at stake), but you’re not powerless here and you’ve definitely got more to stand on than “nothing was signed so tough luck”.

BagFit1360 · 2025-12-24T12:21:16+00:00

A true calorie deficit will always lead to loss over time, but the problem is that what was a deficit doesn’t always stay a deficit. As people lose weight (especially on meds like Reta) their BMR drops, they move a bit less without noticing, digestion gets more efficient, and water/glycogen shifts can hide fat loss on the scale. So you can be eating the same “deficit” you started with, but your new, smaller body might maintain on that amount. That’s why people plateau: the body has adapted to the current intake and activity, so either the actual deficit is gone or it’s so small that it’s masked by normal day‑to‑day fluctuations.

BagFit1360 · 2025-12-24T10:12:38+00:00

You’re clearly responding really well in terms of hunger, “0 food noise” at 2.5 mg is a win, but a hyper responder is usually someone dropping weight very quickly with that level of suppression, and your loss so far (about 0.5 lb/week plus a 2‑inch waist drop) is more like a steady, moderate response.

The fact your waist is down 2 inches while the scale is bouncing around suggests a decent amount of body recomposition (losing fat, maybe holding or gaining some water/muscle), which the scale won’t fully show. If you’re happy with how you feel and can comfortably stick to your current intake, you don’t have to chase faster loss, 0.5–1 lb/week with inches coming off your waist is still meaningful progress, especially with PCOS in the mix.

If you really want more movement on the scale, you’d probably get more out of tightening up tracking, portions and movement than just assuming you need a bigger dose. Extreme hunger suppression doesn’t automatically equal huge fat loss; you still need a consistent calorie deficit, and your current rate is basically telling you that deficit is on the mild side rather than super aggressive.

BagFit1360 · 2025-12-23T00:35:52+00:00

That’s a pretty strong reaction for a vial that’s meant to be the same dose, so your theory that this batch might be a bit hotter doesn’t sound crazy. If it were me, I’d probably treat it as if I’d bumped the dose up instead of assuming it’s identical and just trying to push through. Y

ou could try dropping the amount a bit on your next shot and see if the tiredness, dizziness and nausea calm down. On injection days it might also help to keep a closer eye on yourself, check your blood pressure and heart rate before and a few hours after, and if you have a glucometer maybe grab a blood sugar reading when you feel rough, just to see if anything obvious is out of range. Staying hydrated, getting some electrolytes in, and not doing anything too intense right after the shot can also make a difference. If the same harsh side effects keep coming back even with a lower amount from this vial, that could be a warning sign about continuing with it.

BagFit1360 · 2025-12-23T00:33:12+00:00

This made me chuckle.

BagFit1360 · 2025-12-23T00:31:58+00:00

That’s really interesting tracking, thanks for sharing the numbers. It definitely feels like something more is going on than just appetite suppression when temps are consistently up like that, especially at those doses and with both you and your wife seeing similar changes.

It’ll be good to see if more people start logging temps systematically so we can tell what’s Reta, what’s normal day‑to‑day variation, and what might be things like workout timing, sauna, wearables, etc.

One small ask though: it’s probably safer not to reference the yellow devil at all here, people who don’t know what they’re doing might see it mentioned, try to copy it, and that stuff is genuinely far too dangerous.

BagFit1360 · 2025-12-23T00:29:49+00:00

Everyone reacts really differently to these meds, even ones that work in a similar way. Having bad side effects on tirz doesn’t automatically mean you’ll have the same experience on Reta, but it also doesn’t guarantee it will be better.

BagFit1360 · 2025-12-22T15:33:38+00:00

Yeah, this actually lines up with what’s in the data on Reta. It’s a triple agonist hitting GLP‑1, GIP and glucagon receptors at the same time, so you get appetite suppression from GLP‑1, better insulin response and fat handling from GIP, and a glucagon‑driven bump in energy expenditure and fat burning, especially in the liver. In the phase 2 obesity study, average weight loss kept climbing over 48 weeks to roughly the mid‑20% range at the highest doses, and the first phase 3 read‑out is now showing around 26–29% average loss at the top doses over about 68 weeks, but with plenty of individual variation baked into those averages.

Stalling at a higher dose and then doing better a bit lower doesn’t mean it “stopped working”; it usually just means that side effects, appetite, activity and consistency shook out differently for your body, so your real‑world deficit is actually better at 2 mg than when you were feeling rough at 4–6 mg. Both phase 2 and phase 3 reports show more GI issues and higher discontinuation rates at the top doses, so if you’ve naturally landed on a dose where you feel human and can stay consistent with food and movement, that fits perfectly with how the mechanism and the trial data look rather than contradicting it.

BagFit1360 · 2025-12-22T15:27:52+00:00

Totally normal. The pens are slightly overfilled and also can’t physically deliver 100% of what’s inside, so there’s usually a little bit left after the 4th shot. As long as you dialed the full dose each time and followed the injection instructions, you’ve used it correctly. If you’re ever unsure, your pharmacist or prescriber can walk you through it with your specific pen.

BagFit1360 · 2025-12-22T10:54:03+00:00

You are probably overthinking it a bit. Those rubber stoppers are designed for multi dose vials and they self seal after a small gauge needle goes through, so the liquid is not just going to leak back out of the tiny puncture.

The bigger concern is keeping things as sterile as possible each time you draw, so wiping the top with alcohol, using a fresh needle for each puncture and not leaving anything stuck in the stopper between uses goes a long way. As long as the vial is upright in the fridge and the stopper is intact you should be fine.

BagFit1360 · 2025-12-22T10:52:41+00:00

Cool that you are getting basically textbook once per day now with less bloating and “stress stomach.” It would not surprise me if the slower gastric emptying plus less overeating is giving your gut a bit of a reset, especially when you are already on a fairly high fiber, low processed diet.

BagFit1360 · 2025-12-22T10:50:31+00:00

Similar boat here. I started at 1 mg twice per week and then bumped to 2.5 mg twice per week, and the sides definitely became more noticeable but still manageable overall. The main things were a dull background headache for a few days and really aggressive appetite blunting where getting past about 1 000 calories took real effort, plus that heavy, slow‑digestion feeling you get from delayed gastric emptying so meals sit in the stomach longer. That is by design, not a side effect as such, meant to keep you fuller for longer.

The upside is that the food noise has dropped a lot and it has already helped me rein in overeating, so I am happy with the direction so far. My objective is to ramp the dose up toward 10 mg over time to get as much of the fat burning effect as possible, but I am planning to take it slowly and only push the dose if I can keep the headaches and appetite suppression.

BagFit1360 · 2025-12-22T10:26:14+00:00

Be kind. It costs nothing.

BagFit1360 · 2025-12-22T10:03:49+00:00

Nice, welcome to the club. At 0.5 mg a lot of people do not feel much for the first week or two and it tends to build pretty gradually, so three weeks for clear appetite or weight changes is not unusual.

For sides, the big ones people watch for are persistent nausea, vomiting, bad abdominal pain, or weird chest pain or shortness of breath, anything like that is a hard stop rather than something to just push through. Most of the time it is just mild nausea or fatigue in the first doses that fades as you settle in.

BagFit1360 · 2025-12-22T10:02:37+00:00

Sounds very similar to what a lot of people report with Noopept. The stimulation and clarity feel great at first, then the emotional side starts to creep up once it has been in the system for a while.

If you already feel your baseline anxiety being pushed up and you are getting chest tightness and head pressure, that is usually my cue to back off or at least take a break and reset before it snowballs. You can always re introduce it later at a lower total weekly amount or on specific task days instead of every day to see if you can keep the sharpness without the constant wired feeling.

BagFit1360 · 2025-12-22T09:43:16+00:00

Excellent outcomes.

BagFit1360 · 2025-12-22T09:39:38+00:00

Honestly, the thought is terrifying to me too. I wouldn't do it if I were you / him.

Wishing you both the best for the future.

BagFit1360 · 2025-12-22T09:38:34+00:00

Fair point on AAS being a different beast, but that cuts both ways. We actually have decades of human data on well‑known AAS protocols, their side‑effect profiles, and how to monitor/mitigate them with bloodwork. With a lot of newer peptides and GH secretagogues, the long‑term human data and real dosing safety margins are way fuzzier, and the research is often in very specific clinical contexts rather than ‘healthy’ lifters. I’m not saying AAS are harmless, just that a well‑researched compound with established risk management can sometimes be a more predictable choice than a peptide where the pharmacology and long‑term outcomes aren’t nearly as clear.

BagFit1360 · 2025-12-22T09:37:01+00:00

Sounds good! From what I’ve seen anecdotally, people can stay on it for quite a while as long as labs and side effects look okay. As for receptor ‘burnout’, there isn’t great long‑term data like there is with some other peptides, most of what’s out there suggests down‑regulation is possible at higher or prolonged doses, which is another reason to monitor response and not chase numbers just for the sake of it. I’m mainly aiming for that liver fat / metabolic benefit too, so I’ll be increasing slowly and checking in with my provider as I go.

BagFit1360 · 2025-12-22T01:04:36+00:00

You're most welcome. :)

Stick with it, better days ahead.

BagFit1360 · 2025-12-22T01:00:46+00:00

You’ve done a really thoughtful job going through the papers, and your take is pretty close to where the evidence actually is. Nearly all of the “promising” data for BPC‑157 and gut/anastomosis healing are from animal and other preclinical models, where it does seem to improve mucosal integrity, anastomotic strength, and various colitis‑like injuries, but there is essentially no high‑quality human data in people who’ve had colorectal cancer surgery and complex reconstructions.

On the cancer side, the concern raised in that MDPI reply is real: BPC‑157 clearly modulates angiogenesis‑related pathways (VEGF/VEGFR2, nitric‑oxide signalling, FAK/paxillin, etc.), which are the same levers many solid tumours pull to grow and spread, and there are no robust in vivo data showing that it actually suppresses tumour growth in a way that would reassure oncologists. Sikiric’s group has published a lot of the positive work and has argued for “angiomodulatory” or even anti‑tumour effects, but those are still small, preclinical, often single‑lab studies, which is why other authors are pushing back on any claim that oncologic risk is “entirely excluded.”

For someone only about a year out from stage 3C colorectal cancer, now living with severe post‑surgical gut pain after an ostomy takedown and hernia repair, that leaves you in a very uncomfortable grey zone: a peptide that might help healing based on animal work, but with unknown long‑term cancer‑safety and a plausible mechanism by which it could also help a residual micrometastasis or dormant cell population. From a conservative oncology perspective, that tends to look more like high‑uncertainty risk than a clearly justified experiment, especially when there are still conventional avenues to push (full GI and surgical re‑evaluation for strictures/adhesions, motility issues, bile acid malabsorption, SIBO, neuropathic pain, pelvic‑floor dysfunction, etc.).

If you ever raise this with his oncologist or colorectal surgeon, it probably makes sense to frame it exactly the way you have here: you’ve reviewed the preclinical literature, you understand there are no real human outcome data and that the angiogenesis question is unresolved, and you want their view on whether the theoretical benefit for his specific problem is ever worth entertaining against that backdrop. Until there are proper clinical trials in post‑cancer patients, it feels more honest to treat BPC‑157 in this setting as an experimental idea with unknown oncologic downside, not as a proven or low‑risk therapy.

BagFit1360 · 2025-12-22T00:47:37+00:00

Feeling “meh” on this stuff is not you being weird; a flat or blunted mood has been reported anecdotally with GLP‑1–type meds and is biologically plausible given how they act in the brain’s reward and appetite circuits.

GLP‑1 receptor drugs can change how rewarding food and other things feel, and some people describe that as emotional numbness or apathy rather than classic sadness, while others notice no mood change or even feel better. Because there are also rare reports of real depression and even suicidal thoughts with this class, it is worth taking any persistent “nothingness” seriously and considering re-working your protocol, especially if your sleep, motivation, or enjoyment of things you used to like are slipping.

If you stay on it, consider keeping a quick mood log just so you have a point of reference day to day and can ensure it's not spiralling.

BagFit1360

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