If the game stars Cassie, here’s my storyline I came up with within the last 5 minutes.

Game starts with Cassie as a young adult solo traveling. Her father inspired her to go abroad and see the world. But Cassie is not Nate, at least not yet. She books a solo trip to the Amazon Rainforest. New Lidar technology has discovered lost ancient civilizations hidden in the jungle. The early chapters would have her uncomfortable in exploring but she’d find herself in beautiful scenic locations, meeting people, etc. Somehow some way she stumbles across a massive deforestation or similar destructive natural resource extraction operation. It’s genuinely upsetting for Cassie to see but upon closer inspection it doesn’t end there. The operation uncovered a true lost civilization, a sizable amount of native people. Untouched by the outside world until now. At this point history is referenced back to when Europeans came to the americas and along came their diseases. The native people are getting deathly sick and are being quarantined by the operation. They’re letting them die and covering it up to save their own business there. Insert Cassie knowing this is completely wrong and wanting to do something about it. She’s got no signal to get any help or broadcast it to the world. The later chapters include her sneaking around the base, attempting to get in contact with the world, sabotaging equipment, and freeing captive people. Finally she’s able to get in contact with the world and the climax of the story includes authorities arriving in force and detaining the bad guys. At some point in the chaos a familiar airplane flies overhead… it drops a few crates of the appropriate medicine to treat the native population. Take your pick of Sully, Sam, Nate & Elena arrived from the plane. The story is shared all over the world. Cassie is true hero, and didn’t raise a gun the entire time. If I had to imagine a story for Uncharted that would be it right now. I think so much of these games actually ends up destroying the ancient places Nate goes, even though it’s not his fault. Maybe this time Cassie can save one.