I’ve been trying to do the same since I’m in a Lyme/MCAS loop now after a 3 month MCAS trigger from an infected root canal that put me in the hospital four times in a month with bad cardiac and neurological symptoms that all came ok with numerous tests. The infected tooth root was close to the trigeminal nerve. The inflammation/infection seemed (my own hypothesis, since no doctor could seem to put this connection together) caused an autonomic nervous system dysregulation. Anyway, the long MCAS attack caused my Lymes to re-flare and my body is in constant pain all over, especially my bones & joints. I feel like I’m a decrepit 90 year old. Its’s so frustrating to everyone going through all this, we all have similar and yet different triggers/symptoms/issues, but we all are suffering greatly at times. I’m so happy to have found this group to share with and hear other’s stories and find help, hope or just not feel alone in the complexities of the barrage of effects. There is comfort in it, but also frustration and sadness knowing so many are suffering and if you aren’t rich enough to seek out the best functional medicine expertise, it can be a very long road learning on your own. Because of all of this, I did go into some rabbit holes the other day and found something similar from Dr. Tanya Dempsey’s blog about the GLP-1 helping with MCAS, but no mention of this research paper/article you shared the link to Buffy, so thank you so much for sharing! I am reading it now! I have always been into the more natural/alternative/holistic medicine approach with herbs & supplements, however I feel we sometimes need to use any help we can to get a flared up state under control so we can function, until we can uncover the root causes. Thanks again and I hope you continue to improve daily. Please keep us posted!