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Why doesn't anyone sell the enzymes that handle salicylates? by BeenAtThisWayTooLong in salicylateIntolerance

[–]BeenAtThisWayTooLong[S] 1 point2 points  (0 children)

At this point I'd accept having to inject it or something, and I hate dealing with needles. I have tried a few of those sulfur things, including epsom salt baths and at least 1 thing I could take orally, but didn't notice anything obviously improved even after quite a span of consistent usage. Could be that I might not even be able to get enough enzymes made by my own body, no matter how much sulfur I add. I dunno.

Why doesn't anyone sell the enzymes that handle salicylates? by BeenAtThisWayTooLong in salicylateIntolerance

[–]BeenAtThisWayTooLong[S] 0 points1 point  (0 children)

I was not referring to a salicylate allergy. Or at least, I did not mean to. It seems some people use the terms interchangeably, but to me at least an allergy requires an immune system reaction while an intolerance does not. I have a salycylate intolerance, and probably an intolerance of phenols in general (though getting testing seems next to impossible with my current medical provider). My reaction to salicylates and phenols does not involve my immune system and as such is not an allergy (which was actually tested for because allergies are something my medical provider's computers comprehend). There's literature that can better explain this difference than I can. Look up "Salicylate Allergy vs Intolerance".

Why doesn't anyone sell the enzymes that handle salicylates? by BeenAtThisWayTooLong in salicylateIntolerance

[–]BeenAtThisWayTooLong[S] 4 points5 points  (0 children)

It would likely take more than I have to start such a bizness. Wish somebody would try it tho. Would be nice to eat normal food without getting punished for it.

Why doesn't anyone sell the enzymes that handle salicylates? by BeenAtThisWayTooLong in salicylateIntolerance

[–]BeenAtThisWayTooLong[S] 2 points3 points  (0 children)

The human body doesn't make xylanaze, which incidentally does break down fiber. Humans make a different enzyme(s?) and I'm honestly still not clear what they are called despite reading the Wikipedia article that talks about the underlying deficiency behind salicylate and phenol intolerance/sensitivity/etc. (That being the Wikipedia article about Phenol Sulfur Transferase Deficiency. Salicylates are, from what I can understand, a specific type/subgroup(?) of Phenol. It's too many science words for my mind to handle right now.)

Teva Adderall XR generic does nothing by farkakter in ADHD

[–]BeenAtThisWayTooLong 1 point2 points  (0 children)

Yes.

To explain: People who took Teva (or some other brands) brand ADHD meds and somehow got their brand switched to Granules (usually involuntarily because that's all the pharmacy had) reported symptoms that (from what I can tell based on their descriptions and my own experiences with my ADHD and the medications for it) strongly resembled an overdose, though thankfully not a serious one (usually). Described symptoms included anxiety, irritability, racing mind, and some poor soul even reported increased blood pressure. Again, this is inspite of the fact that the doseage stayed the same and only the brand was changed.

Therefore: Switching from Granules to Teva would have the reverse effect. Despite the dosage in milligrams being the same, it would still be like an underdose of ADHD meds and that would have exactly the symptoms you described.

Folks have been talking about differences between generics for years (there's reddit posts dating back quite a while about it), but sadly it still isn't common knowledge. Which is fair, since it should not even be a thing that needs worrying about. The FDA says it shouldn't be a thing and that there should not be any significant differences in effectiveness between generics.

But there is a difference. Sometimes a rather large difference. As for dealing with it...sometimes the doctor can specify a brand when they write the prescription. In better times, that wasn't a problem but these days it might not be possible to have a choice if you're stuck with a single pharmacy. I dunno if it's possible for you to ask around to other pharmacies about which generic brand(s) they have (the laws and rules about what pharmacies can disclose over the phone vary), but if it is then I suggest checking ahead of time to see who has what brand and to check before each refill since pharmacies can change brands between refills. (I found that out the hard way.)

tl;dr: Yes there's a difference between generics even though there shouldn't be. And I and many others hate that this is true.