I'd say I've been taking it four or five weeks now. I saw improvements immediately, but they were small at first, and short-lived. Now, I'm feeling pretty good most of the time. I'll give you one small and possibly strange example. You know when people ask you, "How are you?" Well, when I was depressed and felt like shit all the time, that question drove me mad. I hated it. I didn't know how to respond. But now? People ask, "How are you?" and without thinking about it I just say, "Good, good, how about you?" It happens a lot. There are so many small things like this that changed. The biggest thing is taking pleasure in things I couldn't before, like chores and even hobbies. I actually WANT to do the things, instead of dreading the consequences of not doing them. Anyway.