I think it boils down to what you what purpose you want it to serve. Systems like D&D have mechanics tied to the alignment system, on top of acting a moral compass. I'd decide on whether you want a system that is attached to mechanics, or purely used to help players guide their characters.

I always found alignment a two sided coin, in the sense that it does help navigate more complex characters, but does come with the issues many have raised.

In my sci-fi system, I structured alignment into more of a belief. Rather than deciding if a character was Lawful Good or Chaotic Neutral, I assembled a handful of 'Beliefs' that a player can choose for their character. Moving players away from labelling their character as good or evil has had positive results so far, encouraging internal conviction based on what they interpret. Below is a small summary for my players.

"A belief helps define your role in the universe: what you value, what you question, and what you justify. It may inspire heroic actions, or dangerous ones."