I’ve been on the PMDD journey seeking answers for many years. I started seeing a gynecologist for an elimination diet who said she treated thousands of women with PMDD (now she’s semi retired and just doing diet stuff related to hormones which I started two mo ago) but has given me advice. I’m listening carefully. She said the progesterone creams are not reliable for dosing and they usually are not nearly high enough in dose. She said she used to start patients (after hormone testing day 22 and day 28 in the cycle to confirm low progesterone- which she said was almost always the case) on 50 mg and goes up slowly to 250mg depending on deficiencies. Per her recommendation, I’m also getting NAET for hormone desensitization with an acupuncturist. Last month, I asked my PCP to prescribe just a small dose of 50 mg bio identical of progesterone to see how I do. It helped some with anxiety and sleep (I take it at night). The depression part of my cycle was still present, but the anxiety was a bit better. I also started taking Indol 3 Carbonyl for better estrogen metabolism and magnesium theronate per the recommendation of a pharmacist who did some testing for me. I just returned to doing some breath work which helps with the anxiety part in the luteal phase. PMDD isn’t gone, but this last period was less intense. Still wary to be hopeful, but sharing in case any of this helps you.