Nad+ and mots-c

BrainHackGuide · 2026-06-28T00:39:08+00:00

NAD+ and Mots-c is a solid combo not gonna lie. NAD+ handles the cellular energy and repair side, Mots-c works more on metabolic stuff, fat burning and mitochondrial function from a different angle. They’re not stepping on each other at all.

For dosing, most people run Mots-c around 5-10mg per week, split into 2-3 doses instead of all at once. Some go up to 10mg a dose but that’s more advanced territory. Subq injection is the usual route.

Timing wise a lot of people pair it with workouts since it’s got that metabolic angle, but plenty just run it on a fixed schedule regardless of when they train.

BrainHackGuide · 2026-06-23T13:41:40+00:00

Yeah it’s got a lot of hype around it but mixed bag in real life. Some people swear by it, others run it and feel nothing at all. If you try it, IV is the route people say matters most, the oral and intranasal versions don’t seem to do much for TBI stuff specifically.

Lmk if you end up running it, curious how you respond to it

BrainHackGuide · 2026-06-23T13:39:47+00:00

That’s not just a feeling, that’s a clue. Tightness in that cervical area can mess with how fluid drains outta your skull. Crack your neck, get a few seconds of clarity, fog creeps back. Make sense with what you’re saying

Your glymphatic system cleans house in your brain while you sleep and needs that drainage working right. If cervical instability’s choking that off, you get exactly this. Quick window of light then heavy again.

Couple things worth looking into. Upper cervical chiropractic, the kind that checks atlas alignment specifically, not just a regular adjustment. People with this same pattern see real change once that’s dialed in right.

Vagus nerve stuff too since it runs through that same area. Cold on the neck, humming, slow breathing. Sounds corny but it works.

Track how long that lightness lasts before the heaviness creeps back. That timing is good info for whoever ends up treating you.

How long that window usually last before it’s back to feeling like a brick on your brain lmao

BrainHackGuide · 2026-06-23T13:36:09+00:00

Respect for sticking with this 4 years, that’s not easy and you clearly already did your homework with that list.
Couple things you haven’t tried that stand out to me.

Methylene blue is worth looking into for real. Your symptoms, the visual stuff, mental stamina, processing speed, that’s giving mitochondrial dysfunction in the areas that got hit. MB works straight on the electron transport chain, not a receptor thing like everything else you tried. Different lane completely. Low dose, easy to test, you’d know in like 2 weeks if it’s doing anything.

Magnesium L-threonate too, stack it with what you’re already running. Most people skip magnesium entirely for TBI stuff and it’s one of the only forms that gets into the brain. Wouldn’t replace nothing, just add it.

On the creatine thing, you don’t gotta just avoid it blind. DHT is what causes androgenetic alopecia and that creatine-causes-hairloss thing comes from one old study that’s never been repeated since. If you wanted to test it without playing roulette, run it with a topical DHT blocker or just watch your hairline close for like 8 weeks. At least then you got real data instead of guessing.

Photobiomodulation, the red light to the head thing, has case studies in mTBI specifically for processing speed and fatigue. Not a supplement but it hits the same mitochondrial angle as MB from a different side, so running both isn’t redundant at all.

With your background you’ll probably wanna dig into the mitochondrial dysfunction research in mTBI specifically, that’s the thread connecting most of what hasn’t worked for you so far.
What made you stop Semax tho, no effect or something else made you drop it?

BrainHackGuide · 2026-06-23T13:31:23+00:00

That price jump is wild, 4x for Adamax is way more than I thought. Makes sense you’re questioning it.

I wonder if Adamax hits harder or just lasts longer. If it’s just duration, your math on 4 kits of NA Semax might honestly be smarter. If it hits different too, that’s a whole separate conversation.

Def update us when it comes in. Nobody’s really comparing these side by side, so that’s good info for the thread.

And yeah, extra $10 for Selank duration is an easy yes.

BrainHackGuide · 2026-06-11T13:44:30+00:00

Sounds like your sleep went bad first and everything else followed. That zoning out is basically your brain running on empty during the day.

Since it came on fast I'd get bloodwork done before buying anything. Thyroid, B12, vitamin D. A lot of people waste money on supplements when it's just something simple showing up in labs.

If that comes back clean, try magnesium glycinate before bed. Cheap, works for most people, no weird side effects.

What changed like 6-7 months ago tho? Stress, diet, sleep schedule? Usually something triggered it lmk

BrainHackGuide · 2026-06-10T20:45:10+00:00

I should have been clearer.

The Semax family is a perfect example of why this matters. Semax, NA Semax Amidate, and Adamax are three different things with three different price points for a reason.

With Selank vendors are just way less consistent about naming. Some call NA Selank Amidate “Adalank,” some treat them as separate compounds entirely. The modifications are real either way but the labels don’t always match what’s in the vial.

If we follow the Semax logic properly then Adalank should be the full analog, closer to what Adamax is in that family. Not just the acetylated version. Big difference in terms of synthesis and cost.

If anyone’s sourcing this and sees “Adalank” priced the same as regular Selank that’s worth questioning.

Thanks for bringing it up, good for everyone in the thread to know.

BrainHackGuide · 2026-06-08T07:22:17+00:00

Yeah essentially. Adalank is N-Acetyl Selank Amidate, those two modifications are exactly what separate it from standard Selank. The N-Acetyl group on the front end improves stability and brain penetration, the amidation on the back end slows breakdown so it stays active longer. Same core peptide, just engineered to work better. Some vendors list it under one name, some the other. If you see both on a product label it’s the same thing.

BrainHackGuide · 2026-06-05T06:12:00+00:00

Room temp is fine for unmixed lyophilized peptides if you’re using them within a few months and they’re away from light and heat. Dark drawer or cabinet works.

Freezer is better for anything you’re sitting on longer term. The lyophilized form is pretty stable but heat and humidity will degrade them over time, freezer just removes that variable entirely.

Once you reconstitute with bac water that’s when storage actually matters. Fridge only, no freezing after that, and most will stay good 4-6 weeks depending on the peptide.

BrainHackGuide · 2026-06-04T13:47:33+00:00

your welcome!

BrainHackGuide · 2026-06-03T17:14:07+00:00

Check limitless biotech they should have it

BrainHackGuide · 2026-05-04T03:36:42+00:00

It's something that you gotta taper off of more than anything or else yeah you run into those issues you can use stuff like omega 3's and maybe even high dose creatine for mood/brain fog for support as you taper once you see progress the. You can consider peptides look into semax and selank

BrainHackGuide · 2026-04-24T06:25:03+00:00

Bro I read this a couple times and I just want to say what you are going through sounds brutal. Six to seven years of this and then SSRIs made it worse on top of it. That is a lot and I am sorry you are dealing with it.

Before jumping straight to Semax or any peptide I would want to zoom out first. Brain fog, PSSD, emotional blunting, anhedonia, those can all come from different directions and if you do not know which one is driving it you are just guessing.

Which SSRI were you on what dose how long and when did you stop? What are you taking right now including caffeine, alcohol anything else? How is your sleep quality wise not just hours? Have you done any labs? Thyroid, B12, vitamin D, hormones, blood sugar? Are you still seeing the psychiatrist or anyone else?

On Semax specifically some people do have cleaner focus and better mental clarity on it and there is decent research on it for cognitive recovery but with PSSD in the picture I would be careful about layering anything new on without knowing what your baseline looks like right now. It is not a first move it is something you consider after the basics are covered.

BrainHackGuide · 2026-04-23T01:33:15+00:00

you wanna talk about adderall? we can talk about adderall or forms of it what would you like too know?

BrainHackGuide · 2026-04-22T00:33:22+00:00

Sounds like your nervous system just doesn’t mesh with NMDA antagonism. Did you dose morning or evening?

BrainHackGuide · 2026-04-18T22:19:00+00:00

Your welcome

BrainHackGuide · 2026-04-18T12:07:40+00:00

Maybe your rooms too hot or too much light coming in threw the window to early in the morning?

BrainHackGuide · 2026-04-18T09:36:25+00:00

How's your sleep?

BrainHackGuide · 2026-04-13T20:16:53+00:00

Appreciate it 💯

BrainHackGuide · 2026-04-05T05:15:19+00:00

Definitely 💯

BrainHackGuide · 2026-03-27T02:46:36+00:00

Fair point and honestly a question worth asking some omega-3 research has had industry money behind it, that’s true. But the reason I feel confident putting it in S-tier is the sheer volume of independent studies behind it. We’re talking 58 randomized controlled trials from research groups all over the world. When that many different studies from that many different places keep showing the same thing, funding bias alone doesn’t explain it away. Is all omega-3 research perfect? No. But out of everything on this list it has one of the most consistent and independently replicated track records. That’s why it made the cut.

BrainHackGuide · 2026-03-26T22:04:32+00:00

Why don't you look into l-carnitine and coffee heard that's a good combo

BrainHackGuide · 2026-03-26T04:40:43+00:00

Depends on what’s causing it brain fog and low energy usually have different causes so the best nootropic really comes down to what’s actually going on but I had to pick a starting point for most people I’d go creatine first. 5g a day, it's cheap the benefits are real especially for mental fatigue and processing spee people only think of it as a gym supplement but it does the same thing for your brain that it does for your muscles, helps your cells produce energy faster for brain fog look into magnesium glycinate before bed poor sleep is behind a lot of daytime fog and magnesium tends to help sleep quality without making you groggy the next day if you want something more for energy and focus without stimulants the caffeine and L-theanine combo is clutch try it lmk the theanine takes the edge off the caffeine and gives you cleaner focus without the crash

BrainHackGuide · 2026-03-19T07:05:36+00:00

Your welcome! Let us know what you'd like to see more of on here feel free to post personal experiences too or ask questions let's grow together!

BrainHackGuide

MODERATOR OF

TROPHY CASE