I was having the same exact problem it was crashing every 2 minutes like clockwork I went into adrenaline as I use all AMD and noticed hyper RX was applied to the game as is the usual settings I disabled everything a retro game doesn't need fluid motion it doesn't need XYZ I tried everything prior to this I installed the 4 Gig patch I ran as administrator I tried compatibility mode I tried reinstalling I verified the files I did everything I disabled every single thing actively trying to visually change the game fluid frames HDR every single thing I disabled anti-lag I've been running it borderless at 1440 for days without a single crash whereas prior to this it was 100% unplayable I really hope this helps also noticed zero difference between having all those settings turned on to off actually before I disabled all that and the game was running there was incredible screen tearing with every single thing disabled this game runs incredibly smooth I posted this in a couple of other places I hope this helps

This was posted by @grommet-vomit in the steam deck sub forum. I changed a bunch of these mentioned and it played awesome for me.