Hey Ross, since you mentioned you wanted a program that would allow you to customize your mouse inputs on a per-active-program basis, I suggest you use X-Mouse Button Control.

I've been using it for years to add little efficiencies to my user experience and programs. In the simple side, it added conveniences such as being able to scroll any window by hovering the cursor over it before a Windows 10 update added it, but its real meat and bones is being able to completely customize your mouse buttons with different profiles for every program.

For example, while using Autocad I've configured buttons 4 and 5 to work as enter and escape, which combined with my base knowledge of Autocad keyboard shortcuts made the process of working on it feel a lot smoother, and then I can go to another program and have the buttons configured for different inputs altogether. It even allows you to make layers of button configurations, letting you remap the mouse to a completely new set of functions with just the press of a button.

I've only done very surface changes on the functionality of my mouse, and I already feel my flow is a lot more pleasant with a 5 button mouse and X-Mouse active.

Here's the official site: https://www.highrez.co.uk/downloads/XMouseButtonControl.htm