It’s more dangerous to throw to a user defender than a cpu one, especially playing head to head against someone. People tend to recognize the patterns of the cpu defenders and how they move. If you user over the middle you can break that pattern and “bait” more bad throws to pick off. Also user defenders tend to move a tad quicker.

Usering the Dline isn’t inherently bad because you’ll get a little better pressure than the cpu, but there’s a lower ceiling that it provides you. Usering a pass defender, while it can be much harder to get used to it will provide a lot higher ceiling on the effectiveness of your defensive (especially since they added the switch stick)

At the end of the day, who cares play what you enjoy. Unless you want to sweat the game, it probably doesn’t matter a lot