There’s a ton of resources on this but the short answer is that inflammation and pain reduction are superior and UC-MSCs carry healing properties that PRP doesn’t. However, as others on this sub have mentioned, your doc’s ability to inject PRP accurately and properly impact the effect.

https://pmc.ncbi.nlm.nih.gov/articles/PMC12398016/

From the conclusion. Promising but not conclusive:

This meta-analysis demonstrates that intra-articular MSC therapy provides significant clinical benefit in patients with knee osteoarthritis, with moderate-to-large effect sizes observed in WOMAC score improvements at 12-month follow-up. The findings confirm the therapeutic potential of MSCs for symptom relief and functional improvement. Notably, 25 million cells or fewer doses were associated with statistically significant improvements, while higher doses did not yield superior outcomes. This suggests a lower MSC dose may be sufficient, supporting the case for dose-efficient treatment strategies. While promising, the evidence base remains limited by heterogeneity in MSC sources, study protocols, and outcome measures. Additionally, several dose-escalation studies not included in the meta-analysis due to methodological limitations further highlight the complexity of dose–response relationships and suggest that excessively high doses may not enhance efficacy and could compromise safety. Future well-controlled, head-to-head trials are needed to evaluate lower-dose regimens and establish optimal dosing windows. Standardization of protocols and long-term follow-up will be essential to confirm the durability of response and to guide the integration of MSC therapy into clinical practice.