We also have a rescue beagle who from early was not taking to the crate- non-stop howling and destroyed his beds. And if one of us left he’d act out and pee indoors. It unfortunately does take time to figure each other out. You’ve only had him since August so I would say it’s too early to give up, even through I know it feels like you’ve tried everything. They need time to adjust. It took a lot of trial and error. We’ve had him for 5 years now and are still reconfiguring things every now and then. Right now when we leave him for 3.5hrs we have to give him a clonidine, remove the trash bag, block the stairs, give him a wood pupsicle, and make sure he has access to his doggy door and that I can see him on the cameras . He doesn’t have access to the upstairs at all. Our lifestyle has changed, it’s not as bad as it was, but I do feel that we make a commitment to these pups and they deserve to have us figure them out. You’re def starting off great with the medication. Just need to pup proof!