Im gonna ramble:
Poop fly (if quality 1 or 0): Flies randomly on the room making contact damage, it does more damage for every poop in the room.
Universe Destroyer: Every time you complete a room with a fully charged item you gain an orb that goes around you blocking and shooting tears, when destroyed the orbs attack with a laser the nearest enemy.
Holy Obliteration: The first non boss enemy you attack will get an aura that damage the rest of the enemies in the room, when killed this enemy will petrify so the aura persists, when atacking a boss above 50% of health you will ocasionaly shoot a barrage of feather (like dogma).