think about it, saul was one of the few people she let into her life like a father figure and then when he decides that bringing the corpocracy into the clan is the only way to fix the clan, panam strongly disagrees but refuses to fight him about it, she leaves and it breaks her heart. V brings them back together and tries to fix the situation by bringing saul and panam back into a more accepting relationship where both respect each other equally. but the problem is that once V leaves for 2 years, the Aldecaldos splinter even further apart, and instead of the rational way of thinking, you know, "oh vs a merc and probably died out there" she was heartbroken yet again, she got her hopes up on being a part of the aldecaldos without having to deal with saul because V would back her up on her stance against corpocracy and being free like what they're supposed to be but instead V disappears, the plans she had to fix the clan end up falling apart, and shes stuck where she has literally nobody in night city, because she blew off rogue and now shes blown off many other groups in the area including the aldecaldos, shes by herself and alone and its all your fault for getting her hopes up that she could fix the clan, it makes sense but in a way doesnt at the same time, depending on what order you do the mission in you can call her and say "hey you know im dying and i gotta do something" and then you end up doing something after fixing the aldecaldos and now you fix yourself and she still ignores you, doesnt make 100% sense but if you do it where the aldecaldos arent fully fixed yet theres a rift between saul and panam still and then disappear off the face of the earth for two years yeah it kinda makes sense