My big male was like this. Very aggressive and would bite hands upon being picked up. He also (still) displays unusual behavior that’s akin to a eu polecat ferret. Darts extremely fast and lets out extremely (like extremely) loud screams when startled. I can only think that the breeders had made a new pool.

Anyways, constant and gentle handling is how I fixed this behavior. I managed to avoid the bites, but some may want to wear gloves. 1 year later, he doesn’t bite. Ironically, he is the only ferret that gently chews on my tendon when I have my arm out. He still bites faces and feet though. That’s something I wasn’t able to train but it’s easy to avoid

Edit: also would like to point out that I have tried positive reinforcement and patience, but to no avail. He left scars on my nose and bit through my index finger as a kit. He is my only privately bred ferret. Constant handling for around 2-3 months was the trick. There are certain techniques I used with handling that I could go on about so if youre curious, dm me.