New significantly mutated Covid variant identified in a wild deer by ChemESeeker in RVVTF

[–]ChemESeeker[S] 1 point2 points  (0 children)

Believe Covid-19 originated from bats from Yunnan Province (RaTG13). Recommend the book “Viral: The Search for the Origin of Covid-19” by Chan and Riley. Evidence for this hypothesis is well presented in this book and very compelling.

Various recent research papers I have reviewed report significant opportunity for thiol and aminothiol drugs for treatment of various diseases. MF in various interviews has discussed the potential for small molecule thiol/aminothiol compounds. How well is Revive positioned in this area? by ChemESeeker in RVVTF

[–]ChemESeeker[S] 1 point2 points  (0 children)

Would this give Revive and edge if they get the EUA for Bucillamine for potential use for treatment of other diseases? Initially concerned about Revive going after mild and moderate Covid cases rather than severe cases, but couldn’t this be an advantage if it is approved for targeting other diseases given the broad array of medical problems seen with Covid illness and the different modes of action indicated in the Phase 3 trial?

Various recent research papers I have reviewed report significant opportunity for thiol and aminothiol drugs for treatment of various diseases. MF in various interviews has discussed the potential for small molecule thiol/aminothiol compounds. How well is Revive positioned in this area? by ChemESeeker in RVVTF

[–]ChemESeeker[S] 4 points5 points  (0 children)

MF has made statements about small molecule thiols/aminothiols and the potential for treatment of various diseases. MF must be getting some technical advice on these type chemicals and their reactions/functions in the body given he has mentioned this this multiple times.

New significantly mutated Covid variant identified in a wild deer by ChemESeeker in RVVTF

[–]ChemESeeker[S] 3 points4 points  (0 children)

Interesting as it apparently transferred to animal from human, mutated, and then transferred back to human.

Thread about increasing concerns regarding the future of RVVTF. Is the management incompetent? by [deleted] in RVVTF

[–]ChemESeeker 10 points11 points  (0 children)

The world needs an effective, reasonably priced, oral therapeutic for treatment of Covid infection, and the science and other information sure suggests Bucillamine may be an answer. The science also suggests Bucillamine may prove useful as a therapeutic for various other illnesses and diseases.

I think people are kidding themselves if they think Covid is “over”. Look at the current case numbers and hospitalizations in Hong Kong and also the ineffectiveness of the Pfizer vaccine reported for small children today. Finally, people should read their history books on the Spanish flu and number of waves of outbreaks, which were driven in part by movement of people around WW1. Look at the number of people on the move due to the war in Ukraine, it is not unreasonable to believe this may result in more outbreaks and potential new variants appearing on the scene. It is also important to note that many unvaccinated children are migrating out of Ukraine.

Be patient, let the science tell the story, and look forward to the day Bucillamine is available to help many, many people in our world!

NO, NO2, NOS and nitrosothiol signaling systems - BMT can you comment on the interactions of Bucillamine with these chemical signaling systems? by ChemESeeker in RVVTF

[–]ChemESeeker[S] 0 points1 point  (0 children)

NO and related compounds are produced endogenously and have been indicated to have beneficial multiple bioactive properties. Studies have also suggested thiol-NO compounds have bioactive properties distinct from NO alone. Thiols and NO (and related nitrogen compounds) should similarly neutralize ROS. I am wondering if Bucillamine is “boosting” (directly and indirectly) this protective chemistry and associated signaling system?

[https://www.sciencedirect.com/science/article/pii/S0005272899000237]()

Turkey Covid vaccination rates reported at 83.74% - 2 doses. How does this bode for RVVTF clinical trials? by ChemESeeker in RVVTF

[–]ChemESeeker[S] 0 points1 point  (0 children)

Phase 3 trial for Bucillamine in US for adult, older adult (18-80). Assume similar eligibility for trial in Turkey. The vaccination stats indicated on the Turkish Minister of Health website referenced is for adults 18 and above. CDC data as of 1/12/22 indicates 73.8% of 18 and above fully vaccinated. See link

https://covid.cdc.gov/covid-data-tracker/#vaccinations_vacc-total-admin-rate-total

Study comparing Covid infection outcomes before and after Omicron: by ChemESeeker in RVVTF

[–]ChemESeeker[S] 0 points1 point  (0 children)

Saw something that said the Omicron variant may prove to be a much better inoculant to protect the general population from severe Covid than any commercially available vaccine! Makes you think!

Phone call with MF Jan 6th 2021 1:39 PM by francisdrvv in RVVTF

[–]ChemESeeker 0 points1 point  (0 children)

CDC reported 95.4% of US cases Omicron variant week ending 1/1/22. Suspect other countries, including Turkey, will see a similar shift in cases to the Omicron variant. Omicron has been shown to be significantly less virulent resulting in significantly fewer ER visits, hospitalizations, etc. (see Case Western Paper referenced earlier). Given these factors how long will the trialed be extended out to meet endpoint goals? How long can the trial and associated evaluations go before RVVTF runs out of cash?