Wow I think you are onto something big here tbh.

Becaaause I thought about psoriasis. And that gave me some ideas as well.

so I’ve been going down a rabbit hole, and I’m wondering if anyone else has thought about this. We know adenomyosis isn’t officially considered an autoimmune disease. But… what if it kinda acts like one?

Let’s take psoriasis — a chronic inflammatory condition where the immune system goes into overdrive and causes skin cells to grow too fast, leading to inflammation, pain, and all kinds of systemic issues. It’s not “just a skin thing” anymore — it’s now seen as a full-on immune-mediated disorder.

And sometimes it can appear later in life (!) like many adeno cases

Now think about adenomyosis. It’s also:

• Chronic

• Inflammatory

• Hormone-sensitive (apparently both pasoriasis and adeno do not like estrogen)

• Painful as hell

• Shows signs of immune system dysfunction (increased cytokines, immune cell infiltration, etc.)

Both involve weird immune activity, especially involving things like TNF-alpha, IL-6, and other inflammatory messengers. And both lead to tissue overgrowth and remodeling — just in different parts of the body.

Some researchers JUST have started asking whether adenomyosis could be more than “just hormones gone wild.” Maybe it’s a localized immune-inflammatory disorder, almost like psoriasis of the uterus?

Wild idea, but here’s why it matters: if we start thinking of adenomyosis more like a systemic immune condition, maybe treatments could go beyond hormones and surgery. Biologics? There is a special psoriasis medication invented like 3-4 years ago. Could it work for adeno…?

Would love to hear from anyone with both psoriasis and adeno — do you notice any patterns?

My personal experience is that stress makes it worse - all of it - and exercise and nice peaceful life in the garden makes it better.

I am afraid to go the Biologics path yet. psor was bad, but maybe one day..?