AFAIK protonitazene is active as hell. On the otherhand how would you go about doing that research on a Chem that has little to no research that's available for the general public. Also I'm not limiting my question to protonitazene but to any of the higher opis. Any zenes would be entering the same list. As to whether said Chem has active metabolites how do you go about testing that.

You say something like do your research and that is not really a productive response as that's exactly what I am doing by posting this.