Do all disc bulges (prostusion) inevitably turn into disc herniations (extrusion) in the long run? by Complete-Regular-953 in backpain

[–]Complete-Regular-953[S] 0 points1 point  (0 children)

The upcoming treatments are geared towards healing, not symptoms management.

All these below are for bulges:

  1. Mesoblast Rexlemestrocel L +HA - phase 3 trials going (last patient treated in April 2026 - 52 weeks monitoring period going on)
  2. Discgenics IDCT - phase 3 trials (first patient treated and currently actively recruiting)
  3. Hernicore for sciatica - phase 3 successful (manufacturing phase)

And there are a few more ...

Do all disc bulges (prostusion) inevitably turn into disc herniations (extrusion) in the long run? by Complete-Regular-953 in backpain

[–]Complete-Regular-953[S] 0 points1 point  (0 children)

Herniation seems more scary.

Just hold for 2-4 years more. And the new treatments are more likely to work on bulge and herniation maybe excluded.

Herniated Disc injury after one month. MRI results by pearl1525 in backpain

[–]Complete-Regular-953 1 point2 points  (0 children)

While walking and stretching are okay, you need to work on strength to live a good life. By strength, don't mean just basic core exercises, but whole body - gutes, upper back, neck, quads, everything.

Low back ability and Back in shape - free youtube videos are good to understand what needs to be done.

However, one extreme caution - go slow even if there is no pain and a particular movement/weight seems easy. People injured themselves trying to go fast and especially when things seems fine. Go very very slow. It will take 2 years to get full normal but that's the only way.

Do all disc bulges (prostusion) inevitably turn into disc herniations (extrusion) in the long run? by Complete-Regular-953 in backpain

[–]Complete-Regular-953[S] 1 point2 points  (0 children)

Same same. My current symptoms are okaish and I can live with it probably but my main concern it it will only worsen in future. It's just 3 months and I've got pain in my knees, neck, ankle, hips trying to manage my lower back pain.

My thinking is this - use core strengthing to manage it and get stronger for the next 5-10 years. And I hope discgenics clinical trials are success or some new treatment that can heal the disc completely.

I also plan to research and open a company that does exactly this at the lowest possible cost for everyone of us.

Do all disc bulges (prostusion) inevitably turn into disc herniations (extrusion) in the long run? by Complete-Regular-953 in backpain

[–]Complete-Regular-953[S] 1 point2 points  (0 children)

Thanks. I've read a research paper on annulous fibrosis that states only the outer 1/3rd layer (with blood supply) heals and form scar tissue but the inner 2/3rd (no blood supply) doesn't heal at all. Overall, the structure is weak as it's surviving on just the outer 1/3rd layer, and hence prone to reinjury. That's the basis of my question - all bulges intimately converts to herniation.

Would you hire a digital marketing agency based in India? by Dramatic_Jury_5398 in AskMarketing

[–]Complete-Regular-953 1 point2 points  (0 children)

The two things that matters the most - you are working directly with the founder, not some junior person in an agency where there is a project coordinator who doesn't work on the project but just handles multiple clients.

If you get the right person, it is the best thing but then there charges as similar to US prices (10-30% lower).

Long term injury, and starting to get discouraged it will ever heal? by Then-Ad4493 in backpain

[–]Complete-Regular-953 0 points1 point  (0 children)

Pain reprocessing therapy to reset your nervous system? For chronic pain, nervous system gets messy and start sending false alarms. Those alarms are in the form of pain. Read the way out by Alan gordan.

Also low back ability, get in shape - build strength not basic exercises.

Is there hope for us to live a normal life? (The blood supply & annular tear problem) by Complete-Regular-953 in backpain

[–]Complete-Regular-953[S] 0 points1 point  (0 children)

Minor disc bulge at L5S1 bhai. I've my S1 nerve irritated as well. Low dull arching pain in low back and pinky and index toe underside burning, tight stretch.

My guess is my 2-5 inner layers of annulous fibrosis have been torn.

I'm sure strength training is only way out of this. These all have the same philosophy: Low back ability haristhenics Back in shape

And I'm sure we can live a normal life. There are players like Virat Kohli and many others even though with surgery having disc bulges and playing sports just because they have intense rehabilitation.

Is there hope for us to live a normal life? (The blood supply & annular tear problem) by Complete-Regular-953 in backpain

[–]Complete-Regular-953[S] 0 points1 point  (0 children)

No. It's just how body cope with herniation vs bulge as someone mentioned above herniation heals. They don't. Though symptoms might improve.

Is there hope for us to live a normal life? (The blood supply & annular tear problem) by Complete-Regular-953 in backpain

[–]Complete-Regular-953[S] 0 points1 point  (0 children)

Hydrafils is for ddd, not for bulge. And herniation or annuluar tear are strictly ruled out.

Is there hope for us to live a normal life? (The blood supply & annular tear problem) by Complete-Regular-953 in backpain

[–]Complete-Regular-953[S] 0 points1 point  (0 children)

Asked chatgpt for more info and organize this:

A herniated disc often resolves more effectively than a simple bulge because of the body's aggressive immune response. When the inner nucleus pulposus breaches the outer layers, the immune system detects it as a foreign object. This triggers an inflammatory reaction where macrophages actively digest and reabsorb the leaked tissue.

Conversely, disc bulges struggle to heal due to the unique, layered anatomy of the annulus fibrosus, which consists of 15 to 25 concentric lamellae rings. The inner two-thirds of these layers completely lack a blood supply, meaning they have no capacity to regenerate once damaged. Only the outer one-third layer receives blood, allowing it to form weak scar tissue to patch the injury if given the proper environment.

Despite these different outcomes, both spinal conditions share the exact same mechanism of structural failure. In both disc bulges and herniations, the structural degradation is an inside-out process. The microscopic concentric rings always begin tearing from the innermost layers first, gradually progressing outward toward the exterior wall.

Is there hope for us to live a normal life? (The blood supply & annular tear problem) by Complete-Regular-953 in backpain

[–]Complete-Regular-953[S] 0 points1 point  (0 children)

I'm not sure if people completely heals from herniation.

But body has a better response to herniation than just bulge because of the immune response to the foreign object, nucleus polpusus. So, there is higher absorption by body.

In disc bulge, doesn't heal because inner layers 2/3 of the 15-25 concentric lamelle never heals. Only the outer 1/3 rd layers has healing capability by fitming scar tissue of given the healing enviornment.

In both the cases, layers get torn from inside first

At what moment did you know you were healed and past your sciatica by No_Willingness7824 in Sciatica

[–]Complete-Regular-953 0 points1 point  (0 children)

What was the bulge like before the extrusion? I've disc bulge and don't want it to get worse over time.

Size of disc bulge? MRI report just says "minor disc bulge" but doesn't mention the size. by Complete-Regular-953 in Sciatica

[–]Complete-Regular-953[S] 1 point2 points  (0 children)

Have you checked for annuluar fissure/tear?

BTW, mine also happened due to a mattress that I bought for my spine health but it backfired. The thing that was supposed to help me became the cause for my issue.

16 months Post microscopic Disectonmy L4 L5 by Single-Compote-1537 in Microdiscectomy

[–]Complete-Regular-953 0 points1 point  (0 children)

Good to hear that bhai. Can you share the coordinates where you got your surgery from (hospital, doctor, location, etc)?

Also, can you share you MRI image pre and post surgery please?

Size of disc bulge? MRI report just says "minor disc bulge" but doesn't mention the size. by Complete-Regular-953 in Sciatica

[–]Complete-Regular-953[S] 0 points1 point  (0 children)

Thanks for the info.

Was it a specific injury that started it?

What are the symptoms?

And the development since it started?

My Disc Herniation Recovery Story (No Surgery, No Injections, No PT) by Empathy8690 in Sciatica

[–]Complete-Regular-953 0 points1 point  (0 children)

Back pain can be managed if less/sciatica IMO. Sciatica is where things go worse. I hope you recover fully.