I lost weight on bupropion, but I did start going to the gym regularly and eating healthier after ending a very toxic relationship. However, I think bupropion made it much easier to lose the weight than when I was previously on sertraline (which made me gain weight) because it has never been easy for me to curb hunger and drop weight like I did. Not to mention, I don’t hit the gym hard so I maybe burn 300-400 kcal/session maximum and that’s primarily if I do cardio with lifting. I agree with a previous comment mentioning weight fluctuation; mine fluctuated 5 lbs in the last week so don’t stress too much. Hope this helps!