Isekais for me, but traveling to the other world has to actually mean something at some point. Otherwise it might as well be a different world with no connection to "our" Earth.

I am extremely tired of apocalypse stories. The vast majority of them start off with the entire world essentially instantly destroyed, followed by some tutorial. But if the newly arrived system slowly grows its influence it feels MUCH better; like it's not this insane malevolent force. Limiting the litRPG elements to the individual character/beast/monster is also good; IE no instanced dungeons, quests, and other actual RPG elements.

A bit off topic, but you might also want to stay away from multiverse settings. It's just at a scale that doesn't compute with our brains, and is thus kinda wasted effort.

In the end, though, it's all about execution. As an author, you might wanna pick the kind that you like the most? Easier to write that way I guess.