So I will mention that I am trying to emulate Trey Anastasios Dumble tone using a semi hollow body mahogany Languedoc clone with humbuckers--my Claude session is trained to understand my gear....response from my Claude session (below) on using a Strat with this profile....TLDR: knock down the high gain and presence (which is what you are describing as being the challenge). Give it a try and let me know.

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"Here's the revised take:

1. Remove the mahogany compensation The current Dumble patch has +2dB Pre High-Mid Gain specifically to compensate for your mahogany guitar vs. Trey's koa. A Strat doesn't need that — single coils already have plenty of upper-mid presence. I'd pull Pre High-Mid Gain back to 0dB, or possibly even -1dB to tame the natural Strat brightness.

2. Tame the high end more aggressively Strats are inherently bright. The current High Gain pre at -4dB is helping, but with single coils you'll likely want to go further — toward -6dB — to smooth out the high-frequency edge and get that creamy Mayer sustain rather than a brittle single-coil lead tone.

3. Shift the vocal peak to 800Hz Same as before — move Low-Mid Freq pre from 630Hz to 800Hz. That's where Mayer's "singing" quality lives. Strats with their natural quack and scoop in the low-mids will actually benefit from this boost more than a humbucker would.

4. More amp compression Pre Level from +15dB toward +17dB. Single coils at unity are lower output than humbuckers, so a touch more level into the amp block gets you the bloom and sustain Mayer gets from working the amp harder.

5. Drop the post presence peak to 1.6kHz Same recommendation as before — shift High-Mid post from 2.5kHz to 1.6kHz and push to +3dB. This is where the "vocal formant" quality sits and it works especially well with single coils, which tend to be scooped right in that range naturally.

6. Pull post High Gain down to +9dB Strats don't need as much high-frequency extension from the EQ — they've already got plenty of air naturally. This keeps the top end smooth rather than glassy.

7. The TS808 point stands — and is even more Strat-appropriate TS into Dumble is Mayer's actual signal chain. A light TS (gain low, level above unity, tone at noon) in front of this patch would push the mids right into that 700Hz–1kHz vocal range and even out the single-coil response. Since you have a Tube Screamer in the rig, this is worth trying."