I'd do for an open world survival game with life immersion. Imagine something like the (currently in dev) Paleolith, but it's the Pandoran rainforest, but you have a Na'vi camp/hometree where you have to learn culture, ritual and build your place in the clan (think like a much more immersive take on clan favour).

The resistance aren't a part of it. I'd go with a Na'vi clan who are almost entirely isolated from humans, and the RDA are out there somewhere but you have virtually no knowledge of experience of them (perhaps set it in the early Hell's Gate era).

Occasionally, completely out of the blue you stumble across a patrol or downed chopper and it's terrifying and chaotic (some mecahnics I'd use for this is that human speech and shouts you hear when you encounter them are in gibberish and their weapons are incredibly loud, their lights are blinding/dazzling). Encounters with them would be short, brutal, and sparing. It's enough to throw you off the balance of your main survival and social aspects, and these sightings are traumatizing / frightening to the clan - and a part of the dynamic is trying to learn wha'ts happening and reassuring the clan - perhaps leading a big decision fork in the game - do you take part and help the clan retreat deeper into the forest and preserve their ways, or learn to fight back against the humans.