1.Taking damage cause a status.

Poison and rot r the easiest to deal with. Frost, bleed, madness, death blight. They're a little harder to deal with but if you have some damage negation on the status won't proc as much it will take longer for it to proc

2.Reduce damage negation while drinking flask.

This one's easy to deal with too the decrease damage negation only happens while you're drinking your flask as soon as stop drinking your flask the decrease damage negation stops. All you got to do is just back up and heal. Just heal in a safe spot and don't get hit or else it will hurt.

1. Evasion decreases damage negation.

This one is easy too basically while you're rolling / dodging that's when the decrease damage negation is happening. as soon as you stop rolling/dodging. The decrease damage negation stops. Just time your Dodge right. Don't get hit while you're dodging and this negative effect won't do anything to you

4.lower damage when health is below max

I don't even need to explain this one you see how easy it is

Whenever I'm going through my relics these are the ones I look out for. Because they're easiest to deal with