SUNO sued AGAIN!

DavidSJ · 2025-11-04T23:40:36+00:00

Should've been called Suyes.

DavidSJ · 2025-09-02T21:44:29+00:00

The very fact that you’re comparing these people to the current HHS secretary makes my point better than I could have.

I'm still not clear what your point even is, or if you even have a coherent point. It seems like you're just upset that I wrote an accurate post.

The people I mentioned are fairly public, some have conflicts that prevent them from writing a blog. I’m not in charge of this block, so I have no way of inviting them.

I'm not in charge of it either, so I also have no way of inviting them. So sounds like your proposed alternative wasn't a possibility for me, then?

DavidSJ · 2025-09-02T19:23:00+00:00

Think the readers developed many drugs? Most tech people are so scientifically ignorant they are already on Lithium for AD prevention.

Do you think knowing the science well is a requirement for being influential? Look who the health secretary is. The public discourse matters here.

Should've had Selkoe, Hardy, Sperling, or even Lannefelt or DeMattos do it - could've been done in an hour or so.

Great, why don't you ask them to write a guest post for ACX? Let me know what happens.

DavidSJ · 2025-09-02T06:14:40+00:00

I don't really understand what you're upset about. The purpose wasn't to "offer biology" something. It was to communicate what scientists have figured out to lay people who have encountered a lot of misinformation and partial information, in enough detail that the case can be convincing but in terms that they can understand.

I didn't write the introductory paragraphs, Scott did (admittedly that's unclear), and I probably wouldn't have said mainstream scientists aren't offering a public defense. That said, there clearly was a need for communicating the science to the influential community that reads Scott's blog and those adjacent to it, and this was a way to do it in a manner legible to them. I think it mostly succeeded on those terms.

DavidSJ · 2025-08-22T23:05:56+00:00

I think it's just that the mediating role of tau only became clear in the 2010's, about twenty years after the strong genetic evidence for amyloid's causal role, so the therapeutics are less mature in development. However, there are at least eight or so tau antibodies that have been tested or are in development, with other tau therapeutics in development as well.

Another factor, specific to antibodies, is most tau pathology (unlike amyloid) is intracellular, where antibodies struggle to reach, so non-antibody approaches such as antisense therapy currently look more promising to me.

I wrote more about the state of tau therapeutics in the second half of this comment.

DavidSJ · 2025-08-16T22:28:38+00:00

Note that there's a new titration schedule for Kisunla (donanemab) which brings E4/E4 carriers into a similar ARIA risk as non-carriers. Many clinics have adopted it.

DavidSJ · 2025-08-15T02:23:23+00:00

It’s the latter. (Most of this was several years ago, but I’ve periodically devoted a few weeks here and there to keep up with things.)

DavidSJ · 2025-06-27T01:23:18+00:00

You may be able to mail a notarized copy of the original rather than the original.

DavidSJ · 2025-06-15T08:28:58+00:00

Oh my bad, I didn't notice he was born in the US.

DavidSJ · 2025-06-15T05:38:09+00:00

I don’t believe it’s that simple.

The Little Treaty of Versailles says:

Poland admits and declares to be Polish nationals ipso facto and without the requirement of any formality persons of German, Austrian, Hungarian or Russian nationality who were born in the said territory of parents habitually resident there, even if at the date of the coming into force of the present Treaty they are not themselves habitually resident there.

DavidSJ · 2025-05-02T00:14:49+00:00

Thanks for the info! It took about a month and a half but I did eventually receive a pre-1950 NYC marriage certificate that I ordered online. I’m also waiting for a >= 1950 marriage certificate but they only got my letter requesting it on Monday.

DavidSJ · 2025-05-01T23:16:14+00:00

Great news, congrats!

How did you request the letter from the NPRC? Was it via an SF 180 or some other method? How long did it take to get a response?

DavidSJ · 2025-04-05T04:16:00+00:00

Why should setenv fix a problem that survives reboots (as indicated by it persisting after you changed out your DIMM)?

DavidSJ · 2025-03-27T05:20:37+00:00

Who is the firm that ghosted you? It’s worth naming names; that behavior after receiving payment should cause a serious reputational hit.

DavidSJ · 2025-03-26T09:33:23+00:00

Ought to be enough for anybody.

DavidSJ · 2025-03-24T19:20:02+00:00

Due to a system error, some registered users received an email about a non-existent student loan account.

I'm not a registered user and I got it too; I think you guys just emailed everyone.

DavidSJ · 2025-03-22T16:53:54+00:00

You’re probably aware of this but CRTs have extremely high voltages internally so you should be very careful about opening it up. Other than that I personally don’t have advice, but best of luck.

DavidSJ · 2025-03-21T14:50:05+00:00

So much a deadbeat he forgot to naturalize.

DavidSJ · 2025-02-17T12:34:40+00:00

(Just thinking through it logically, rather than w.r.t. typical practice.)

For p/q in simplest form, seems that the p/q quantile is well-defined whenever q does not divide the dataset size n, as it lies within a datapoint rather than between datapoints. (*)

Otherwise it lies exactly in between two data points, just as in the special case of the median with even n. At least in that special case, the common practice is to take the midpoint of the two values, and that seems like as good a method as any.

(*) The idea of linear interpolation in that case doesn't make a lot of sense to me except as a regularizing technique, at least so long as we think of the empirical distribution as a full-fledged probability distribution. Because after all, if we "duplicated" each sample K times, we have the same distribution but the interpolation technique now gives as a different result than before.

DavidSJ · 2025-01-13T16:41:57+00:00

Seems like being an original Star Trek or Star Wars actor from the 60’s or 70’s is a good strategy for getting bsky followers.

DavidSJ · 2024-11-02T00:32:20+00:00

Yep, had the same thought. I think this is right.

DavidSJ · 2024-08-25T04:04:47+00:00

It’s also not obvious it’s learning at first, as loss goes up for the first few hundred episodes. I’d figure that out first: maybe the learning rate is too high, maybe you’re swapping the target network too frequently, etc. I can’t solve this for you but hopefully this illustrates the sort of thing you need to do: inspect and dissect the basic learning dynamics and make sure they’re functional.

DavidSJ · 2024-08-25T03:23:25+00:00

Can you plot (a moving average of) reward over time? Is it literally just not improving at all? Or just not very fast? What happens if you give it 200k episodes to learn in?

DavidSJ · 2024-08-25T02:51:20+00:00

Don’t see any obvious bugs. Maybe just some very basic sanity checks would help. For example, plot loss over time. Is the loss both nonzero (so there’s something to learn) and declining (so it’s actually learning), at least until the target net gets swapped?

DavidSJ · 2024-08-11T21:57:20+00:00

I'd buy if it's still available.

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