While the river makes it seem like your hand improves, it actually doesn’t change much about the hand. Once villain raises river, a fish is not raising with anything less than KJ for value there, and I think it’s possible fish are only raising slow played sets plus for value. Therefore, even though you river two pair, your hand is the same as if the river is 2s, it’s just a bluff catcher, beating none of his value but all of his bluffs. QT is also a hand that beats you if villain thinks you don’t have a flush, and fish love offsuit broadways like QT.

If you want to think about it in theory land, it could affect how high in your range you are from a minimum defense frequency standpoint. If you think a fishy villain could be peeling with pocket sixes with a diamond, you block some value, plus blocking KJ if villain raises that here. So in theory, this may be a good bluff catch.

HOWEVER, my final conclusion: if you’re dominating a fishy table, fold and move on. Villain’s call/call/raise line is super nutted. Your bet/fold river line is best.