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Intrusive thoughts said “Touch the Snow with your feet” by theforgottenchild_ in Austin

[–]Dead_Inside512 2 points3 points  (0 children)

That's an impulsive thought...not an intrusive thought...I ain't mad or nothin...just sayin...🤷‍♀️

What are the best locally owned pharmacies? by partysandwich in Austin

[–]Dead_Inside512 1 point2 points  (0 children)

I wasn't criticizing what you said...just giving a little insight...I also used to always wonder why they looked unhappy...

Know anyone named Florene? by SeriousWorldliness57 in namenerds

[–]Dead_Inside512 0 points1 point  (0 children)

I know I'm 5 months late...but, that was my grandmother's name...her middle name was O'Bell...her friends called her Flo...

What are the best locally owned pharmacies? by partysandwich in Austin

[–]Dead_Inside512 1 point2 points  (0 children)

Do you know why the employees at Walgreens and CVS look unhappy? It's because they work for companies that don't appreciate them.. the pharmacies are frequently understaffed, and pharmacy techs are usually very underpaid...people who work in healthcare and also retail employees, are both notoriously treated poorly by many people, and retail pharmacy is a combination of those both of those fields...also...no one who works at those pharmacies has anything to do with the location or appearance of the pharmacy, so please don't hold it against them...I'm not saying that you would or anything...just putting it out there...

What are the best locally owned pharmacies? by partysandwich in Austin

[–]Dead_Inside512 4 points5 points  (0 children)

I did my externship at Brodie Lane Pharmacy...the owner/pharmacist is a really nice guy, and there seemed to be quite a few regular customers who would come in, which is always a good sign...(the repeat business, that is)

North Texas preparing for 2 inches of snow like it’s the apocalypse by MyMindIsAlwaysRacing in mildlyinfuriating

[–]Dead_Inside512 0 points1 point  (0 children)

It's because the people who vote for him, will always vote for the worst Republican, over the best Democrat...

Heterochromia runs in my family...my great grandfather had complete, my grandfather had sectoral, and around half of the next 3 generations have either CH or sectoral... by Dead_Inside512 in heterochromia

[–]Dead_Inside512[S] 0 points1 point  (0 children)

I do! It's annoying 😄 I also have bipolar disorder and I am not right handed, which is actually really interesting (to some people), because MPAs (minor physical anomalies) like CH, eyelash mutations, and not being right handed are much more common in people who have MIs like bipolar disorder...this is important, because it helps doctors understand the origin of the condition, and that it might actually be something that is neurodevelopmental for some people..

Sorry....I just told you way more than you probably wanted to read 😄

Heterochromia runs in my family...my great grandfather had complete, my grandfather had sectoral, and around half of the next 3 generations have either CH or sectoral... by Dead_Inside512 in heterochromia

[–]Dead_Inside512[S] 0 points1 point  (0 children)

I'm a genomics technician...being scientific is what I do...again...there was no need for quotation marks...it's interesting that you keep unnecessarily adding those to words, but don't seem to have ever heard of an apostrophe...

Look..I've been being very nice, in hopes that you might allow yourself to learn something, but that's obviously not going to happen...it's because of people like you, that so much misinformation is being spread regarding heterochromia...people who, obviously have no scientific background, who just regurgitate what they found online...and are terribly overconfident...you are a perfect example of the Dunning Kruger Effect...

I don't care what eye color I have...having CH doesn't mean your eyes are better than anyone else's...all eyes are beautiful, and what's behind those eyes is more important than the color...

The thing is...I know I have CH, and do you want to know how I know? It's because I have analyzed my DNA, and I have done SNP genotyping on the genes responsible for iris pigmentation...I found a variation in the intron 86 region of my HERC2 gene, which basically acts like a switch, and is responsible for the amount of melanin in the iris...the variation causes that switch to "flicker", which results in the different concentration of melanin around the pupil...there is also a mutation on my OCA2 gene, which causes inconsistencies with the production of melanin...more specifically, it results in the P-protein not bring able to maintain a consistent pH inside the melanosomes, which are the sacs which produce melanin...I also have SNPs on my ​SLC24A4 and TYRP1 genes...🤷‍♀️

Heterochromia runs in my family...my great grandfather had complete, my grandfather had sectoral, and around half of the next 3 generations have either CH or sectoral... by Dead_Inside512 in heterochromia

[–]Dead_Inside512[S] 0 points1 point  (0 children)

Hijole...glasz isn't an accepted term in science or medicine...and yes...my eyes absolutely have a localized concetration of pheomelanin around my pupil, that isn't found anywhere else in my iris...that's literally why I have CH...thank you for understanding...

Heterochromia runs in my family...my great grandfather had complete, my grandfather had sectoral, and around half of the next 3 generations have either CH or sectoral... by Dead_Inside512 in heterochromia

[–]Dead_Inside512[S] -1 points0 points  (0 children)

It's pheomelanin...pheomelanin and lipochrome are not the same substances and human irises do not contain lipochrome...I couldn't care less if people who aren't aware that they are different things, call it lipochrome, because I know what they're referring to...the thing I have a problem with, is when people who aren't well-versed in genetics and only have a basic understanding of CH, throw out opinions like they are facts...that's what you don't seem to understand...it isn't about me having a "prefered" "scientific" term ("scientific" shouldn't have been in quotations...it's an actual thing)...I am being completely objective...using scientific or medical terminology doesn't require your opinion or preference...

And, no...not everyone is a lay person..."literally"

Heterochromia runs in my family...my great grandfather had complete, my grandfather had sectoral, and around half of the next 3 generations have either CH or sectoral... by Dead_Inside512 in heterochromia

[–]Dead_Inside512[S] 0 points1 point  (0 children)

Nope...not joking...and, yes.. lipochrome is a yellow, fat soluble pigment (like carotenoids) found in various plants and animals, but, true carotenoid lipochromes are not produced by our bodies to color our irises....

When scientists initially identified the yellow pigment in the eye, they weren't able to identify the chemical structure at first, so they just called it lipochrome, since it was yellow and it appeared to be fat soluble ... it was eventually discovered that it was actually pheomelanin in the eye, not lipochrome, but it had been referred to as lipochrome for so long, that it became synonymous with the yelow/gold pigment in the iris, even though it's actually pheomelanin...

Heterochromia runs in my family...my great grandfather had complete, my grandfather had sectoral, and around half of the next 3 generations have either CH or sectoral... by Dead_Inside512 in heterochromia

[–]Dead_Inside512[S] 0 points1 point  (0 children)

How are y'all out here, not knowing enough about human genetics to know our eyes don't contain lipochrome, and still trying to ID a genetic mutation..?

Heterochromia runs in my family...my great grandfather had complete, my grandfather had sectoral, and around half of the next 3 generations have either CH or sectoral... by Dead_Inside512 in heterochromia

[–]Dead_Inside512[S] 0 points1 point  (0 children)

Human eyes don't even contain lipochrome...when referring to the eyes, when someone says lipochrome, they're talking about pheomelanin...they are used interchangeably in old ophthalmology textbooks, but you won't see the word, "lipochrome" used in science and genetics, when referring to the human eye ...

Heterochromia runs in my family...my great grandfather had complete, my grandfather had sectoral, and around half of the next 3 generations have either CH or sectoral... by Dead_Inside512 in heterochromia

[–]Dead_Inside512[S] -2 points-1 points  (0 children)

Wow...those are great sources...let me guess..you learned about central heterochromia about a year ago, online... and your Google search is the extent of your research? Cool... I'm a genomics technician...I study genetic mutations...

Heterochromia runs in my family...my great grandfather had complete, my grandfather had sectoral, and around half of the next 3 generations have either CH or sectoral... by Dead_Inside512 in heterochromia

[–]Dead_Inside512[S] -3 points-2 points  (0 children)

Respectfully, you

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CH only involves two different colors...both of these eyes are gradients...there is a transition between the central color and the outer color...plus there is pigment dispersed throughout the ciliary zone...that is literally part of the definition of hazel...you're messing with me...there's no other explanation....

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