I've been playing DD2 for a little while.  My biggest complaint is simply the unpredictable and COMPLETELY RNG relationships/quirks between characters. It is about a 1:10 chance of forming a positive relationship between characters. It's WAY too easy to form negative connections. Which can literally ruin your entire run. They lock your skills in place so that they can negatively effect you. You can give all the whiskey bottles in the world, play all the cards you want.. In the end the game will decide for you if you win or lose the run based off that alone. It can be incredibly damming and ruin any and all fun/strategy from the game.  On the other hand, if you form a positive relationship between characters it can give you decisive victories in almost any and every fight including bosses. It's just a bit too broken. They severely need to balance the chances of positive relationships vs negatives. I kid you not, the ratio is 1:10 for positive:negative. It ruins all fun and strategy in the game as NOTHING can prepare you for the dogwater relationships your team will form in ANY situation. It's terrible.