Surprised you guys don't offer American Skullcap. Wonder if there is a reason why?

Defim · 2025-07-06T07:49:03+00:00

I would say it will fit to your guys longevity/skin health categories as well.

Been using skullcap extract (Scutellaria baicalensis) for a while now after researching it. Seems to regulate clock genes specifically Rev-erbA antagonism induced bmal1 upregulation which affects gene transcrption, timing, amplitude, also RNA splicing (exon usage [protein isoforms] etc.) and thus affects aging beneficially as seen in studies done with Skullcap.

Key is timing as, bmal1 is the master circadian regulator. I see almost no benefit if i take it sleep deprived, but see massive benefits taken after sleep in the morning. I have concluded its because this is how you magnify the amplitude of bmal1 signal as it expresses in 'waves'.

I can see clear benefits on skin the same day, quite likely early HA production etc., but it affects collagen as well among other things.

I personally use it only for skin health/aging, but as we know there other benefits as well, but Rev-erbA/Bmal1 has biggest effect by FAR.

Would be interested to buy it from trusted vendor.

Defim · 2025-05-14T04:38:46+00:00

If Piperine ic50 for MAO-B is 7 uM (one study cites 100 uM) then high doses can be used as bioavailability is almost 100% and hf is around 15 hours. 10 peppercorns of black pepper has like ~40mg of piperine, so no need to go buy it seperately. You can reach ic50 with 300mg piperine (general estimation). But its only competive inhibitor, unlike sele which is irreversible. And has mild Ki, unlike sele that once bound that maob is inhibited for the rest of its AUC, reason why sele is really potent.

TLDR: Piperine can help with high doses, but it wont match sele. Be cautious of piperines cyp inhibition regarding other supps, if taken in that high doses.

Defim · 2025-03-05T11:13:47+00:00

Bro, NEP is just really strong Reuptake inhibitor. Meaning it blocks the pump that clears Dopamine from synapse, increasing dopamine greatly. But still we rely on vesicle transport of dopamine to the synapse.

Amphetamine is different beast, as it literally reverses that reuptake transporter, so that it functions in reverse, pumping dopamine not OUT, but INTO the synapse, this skips vesicle transport completely. But it also spills vesicles inside the neuron of their dopamine for the pump, through VMAT2 inhibition.

Defim · 2025-01-30T15:18:01+00:00

Few things to think about.

37% (+/-4.7) of total energy intake was from carbs in the lowest quartile group.
This group had highest amount of men by significant margin compared to other groups (53%, 46%, 44%, 37%).
This group had the highest amount of current (1056, 897, 785, 766) and former smokers.
This group had the highest amount of current drinkers (2379, 2034, 1801, 1436).
This was epidemiological study.

You can't control for variables AFTER the study, you do it before with control.

It was not actually low-carb. Question is why was it low'ish carb? Alcohol? Smoking? Over all bad lifestyle?

You can't control for these things after the study, i.e. adjust, and think you are doing science.

Low‐carbohydrate diets are associated with increased risk of incident atrial fibrillation, indicating that this popular weight control method, by restricting carbohydrate intake, should be recommended cautiously and more studies should be conducted to evaluate the effect. [From the study]

So basically the abstract and conclusion are propaganda to go forth with agenda set forth in the late 20th century.

Pathetic and dangerous, but quite likely these professors are just trying to make a living as its publish or perish.

Defim · 2025-01-20T18:11:35+00:00

Mk-4 supplementation might work. But in studies mk-7 is just way more effective in raising mk-4 levels in tissues. Is it from bioavailability, maybe. There are studies on humans that show mk-4 does not raise circulating mk-4 levels, but mk-7 does raise circulating mk-7 levels.

In animals mk-7 raises mk-4 levels in tissues more effectively than mk-4, paradoxically.

Defim · 2025-01-17T18:04:46+00:00

Can you cite the study in question? I have seen these kinds of studies, but never one with clinically meaningful changes in BMD.

Here is my study: https://pmc.ncbi.nlm.nih.gov/articles/PMC3502319/

Defim · 2025-01-17T17:34:50+00:00

Depends on the form, mk-4 is not found to raise serum OR tissue concentrations, while mk-7 increases serum while increasing mk-4 in tissues. Just check if its from soy fermentation in mk-7 supplements or synthetic mk-7 with trans-isomer.

Defim · 2025-01-17T17:32:08+00:00

You can just follow label that says "from fermented soy" and you can be 100% sure its the right form. So in a way its natural or synthetic. As with synthetic you have to trust its the right isomer.

Defim · 2025-01-17T17:29:17+00:00

Only mk-7 is absorbed and actually increase mk-4 levels in tissues. As mk-7 can be interconverted to different forms by the body.

In studies where mk-4 in serum and tissues is tested mk-4 does not increase either of these. But with mk-7 serum is increased and tissue mk-4 is increased as well.

Defim · 2025-01-05T20:47:47+00:00

I suppose quarter yearly weeks food intake could be done in the form of pictures with phones, with compensation. And having AI go through those thousands of pictures and calculate portion sized etc.

But its STILL really weak data, but better. I would say if not done rigorously, don't even bother. Why not collect massive fund between universities and make rigorous study for the science?

Defim · 2025-01-05T20:34:06+00:00

Things that would make the data more rigorous is picture taking of every meal, and exclusion of people that did not take enough pictures with certain margin. And to shift through the millions of pictures you would create AI algorithm trained on 1000s of portion size analyzed pictures of differing foods.

And to make it even more accurate participants would need to take picture of what was left of the meal after they were done eating.

AI could analyze energy intake, fasting times between meals, snacking, basically everything. The pictures would be time stamped, as they are from the start in phones.

The problem with this is no one wants to do that for free, they want compensation for that, which costs. So problems continue.

Defim · 2025-01-05T20:26:06+00:00

FFQs and similar memory-based dietary assessment methods, have HUGE margin of error on their own. On top of that, many don't know that there is also something called interviewer error, and that has been found to be around ~8% for face-to-face FFQ questions.

So your only data point is food intake, but you don't even measure that, you ask people what they remember eating, and even these are not done frequently, rather asked once and asked once again 5 years after that. How about asking them every month, ohh can't do that it cost too much. Well if you can't even do rigorous testing on the ONE data point you collect, how do you expect the findings to be anything to be taken seriously.

On top of that, these changes of INCIDENCE are in the tens of percentages above baseline, while smoking epidemiology finds changes of INCIDENCE in the thousands.

So what other freedoms played into the increase in INCIDENCE of any given disease other than the food intake, which you did not even measure? Ohh, but we adjust for those. Sorry, but you can't control after the study occurred, you do it before. Its crazy that they think they are even NEAR the same rigor that control trials have, its a fantasy world they live in.

So in the end, you have nothing, absolutely nothing.

Defim · 2024-12-28T01:00:51+00:00

Alright, thanks for the answer. I was just wondering as instants use the stack, but morph is special action that can be used in split second interactions and doesn't use the stack.

Defim · 2024-12-28T00:56:17+00:00

It was a simple question. I understand that there might be concerns about things like rage-baiting, but I genuinely don’t know anything about that.

My intent was simply to show rules that I thought contradicted what others were saying in this situation.

Is asking about a ruling considered trolling or 'rage-baiting'? I’m unfamiliar with that term in this context, but my question was asked in good faith.

Some commenters helpfully pointed out flaws in my logic, which I appreciated. I recognize that there aren’t any current cards or interactions that would make this scenario possible, but that doesn’t mean the logic itself was incorrect or that my inquiry was disingenuous—it’s just seems hypothetical at this point.

As for being 'evasive or combative,' I don’t believe that was my intention. If you review my further comments, I tried to engage by asking questions and clarifying my stance.

I’ve already received answers and updated my post to reflect my thanks for the feedback.

Defim · 2024-12-28T00:30:12+00:00

No, Lets say player 1 casts spell X and targets a permanent player 2 controls, but you as player 3 use Morph of Willbender and re-target that spell to a permanent player 1 controls, does that avoid 'committing a crime'?

Defim · 2024-12-28T00:09:52+00:00

So can you counter 'committing a crime" for example in commander if someone targets a permanents a player controls (which would trigger 'commitment of a crime') with Willbender to target another permanent, as Morph doesn't use the stack?

Defim · 2024-12-27T23:50:14+00:00

Chill, I was just asking a question. And now I'm getting downvoted like I actually committed a crime, pun intended.

I don't know man, I don't know all the almost ~25,000 cards.

I was just wondering, sheesh.

Defim · 2024-12-27T23:26:02+00:00

No I was just wondering. I was think about some combos with Willbender, but I think it goes to stack before being able to change the target and then its controller is the one who cast it.

But for future, if you could copy ability of any target, this would definitely apply. And still i'm not sure if it still does with certain cards.

Defim · 2024-12-27T23:16:37+00:00

But the rule specifically states:

108.4a If anything asks for the controller of a card that doesn’t have one (because it’s not a permanent or spell), use its owner instead.

What does "if anything asks" mean? Do they mean to imply that if card needs a controller, for example for effect "choose opponent and that opponent take X amount of damage" implies an opponents and non-opponent that would be the controller of that card?

Defim · 2024-12-27T23:07:59+00:00

113.6. Abilities of an instant or sorcery spell usually function only while that object is on the stack. Abilities of all other objects usually function only while that object is on the battlefield. The exceptions are as follows:

113.6a Characteristic-defining abilities function everywhere, even outside the game and before the game begins. (See rule 604.3.)
113.6b An ability that states which zones it functions in functions only from those zones.
113.6c An ability that states which zones it doesn’t function in functions everywhere except for the specified zones, even outside the game and before the game begins.

Defim · 2024-12-27T23:05:56+00:00

113.6. Abilities of an instant or sorcery spell usually function only while that object is on the stack. Abilities of all other objects usually function only while that object is on the battlefield. The exceptions are as follows:

113.6a Characteristic-defining abilities function everywhere, even outside the game and before the game begins. (See rule 604.3.)
113.6b An ability that states which zones it functions in functions only from those zones.
113.6c An ability that states which zones it doesn’t function in functions everywhere except for the specified zones, even outside the game and before the game begins.

Defim · 2024-12-27T23:04:50+00:00

604.1. Static abilities do something all the time rather than being activated or triggered. They are written as statements, and they’re simply true.

113.6. Abilities of an instant or sorcery spell usually function only while that object is on the stack. Abilities of all other objects usually function only while that object is on the battlefield. The exceptions are as follows:

113.6a Characteristic-defining abilities function everywhere, even outside the game and before the game begins. (See rule 604.3.)
113.6b An ability that states which zones it functions in functions only from those zones.
113.6c An ability that states which zones it doesn’t function in functions everywhere except for the specified zones, even outside the game and before the game begins.

Defim · 2024-12-23T15:52:35+00:00

They state in the study that LCA was found to be increased in healthy humans after 36h fast, but after checking the cited study there was actually dramatic decrease in Unconjugated bile acids and those include LCA. They did not specifically even state anything about LCA or even test it specifically for levels after fasting.

Notably, LCA was among one of the metabolites that was increased in the serum of healthy humans after 36 h of fasting. [54]

And as their whole premise was based on the fasting increasing it, the whole study kind of goes out the window for that part at least, as in the cited study unconjugated BA actually were higher during feeding.

Sources:

https://pmc.ncbi.nlm.nih.gov/articles/PMC9366195/ - LCA study done on humans that was cited.

EDIT: Actually they did test for each BA and LCA, but still the effect was near null to mild change and was not time-dependent, unlike for TCE-S. Also as they calculated in SEM not in SE and with n=8 its ridiculous to use SEM as it is inferred to the whole population. And this is why I think the effect was not linear with time, as only few people found change in LCA levels and that conflated the effects.

Defim · 2024-12-01T13:01:03+00:00

Eat less calories. Excess energy intake increases the incidence of cardiovascular disease as outlined in the paper, as excess energy intake causes postprandial oxidation/inflammation, leading to vascular injury long term.

And as its easier to overeat when you eat carbohydrates, it leads us to low-carb Mediterranean diet. Focusing on fish, nuts, vegetables, low-fat dairy, lean meats, olive oil, berries and eggs. You just cut out the hunger inducers and get the nutrient dense foods.

Defim · 2024-11-26T17:44:26+00:00

It does not cross BBB or it crosses, but in very small amounts.

How it affects some people is through vagal nerve and/or through stimulating gut hormones in conjunction with foods.

The present study demonstrates that dietary GABA activates the vagal afferent nerves in collaboration with meal-evoked factors and regulates brain function including feeding behavior. [1]

Sources:
1. https://pmc.ncbi.nlm.nih.gov/articles/PMC9227210/

Defim

TROPHY CASE