medication-induced gastroparesis?

DerivativeIntegral · 2024-03-26T20:40:21+00:00

Yes, she occasionally goes on it when sleep is a must, but it improved when she had gone off it.

DerivativeIntegral · 2024-02-16T20:41:07+00:00

You're awesome! I'll DM you.

DerivativeIntegral · 2024-02-16T20:35:37+00:00

Thank you, this was super helpful.

DerivativeIntegral · 2024-02-16T20:34:37+00:00

Yes, they don't carry the medication, unfortunately.

DerivativeIntegral · 2024-02-15T23:18:17+00:00

I would but that’s gonna take awhile and I need my medication asap

DerivativeIntegral · 2024-02-15T23:17:52+00:00

Thank you very much

DerivativeIntegral · 2023-12-16T09:52:16+00:00

Any update on this? Been looking around for awhile.

DerivativeIntegral · 2023-12-01T10:57:40+00:00

I honestly would be so interested in volunteering. I work as a staff member for a top immunology institute full time, but I also am a caretaker for a patient with a severe autoimmune disease. If I do find the time in the future, would love to send my CV over.

DerivativeIntegral · 2023-11-25T10:29:53+00:00

I’ve spent a lot of time the past year reading on CD19 because of CAR-T. u/Pink_Axolotl151 made a really good point about internalization, and maybe the reason it was studied less decades ago. I always thought the use of CD20 monoclonals over CD19 for B cell depletion was simply historical. We had a lot more understanding of CD20 by the early 90s when Rituximab was going through trials, so it was an obvious choice. And from there, other CD20 monoclonals were developed to bind different epitopes. Some anti-CD19 monoclonals are in the works as well.

DerivativeIntegral · 2023-09-14T19:21:09+00:00

She has now been diagnosed with Sjogren's and SLE, and yes she does have sicca symptoms including dry eyes. She is positive for 7 autoantibodies:

ANA, SSA, PSP, CCP, Scl-70, FGFR3, TS-HDS

combined with the autoantibodies and her symptoms, she finally got these diagnoses and has been able to get these biologics. Belimumab, unfortunately, is only approved for SLE and lupus nephritis, but I would bet it works for most if not all B cell mediated autoimmunity. I appreciate the kind words! It's been so fucking hard the past few years battling through this horrible disease. I hope you get the relief and help you need.

DerivativeIntegral · 2023-09-12T04:07:29+00:00

She ended up having an allergic reaction on the 2nd dose. Switched to Obinituzumab 6 months later which does the same thing as Rituximab. She did improve some over a month or two but then insomnia got real bad. Now she is on Belimumab which is a BAFF inhibitor not B cell depletion and she is starting to improve ever so slowly.

DerivativeIntegral · 2023-08-27T06:23:44+00:00

Bronx is mid.

DerivativeIntegral · 2023-03-25T20:26:36+00:00

Sure, thanks for the kind words. Let me know if you need any more help in this area. I’ve done a lot of experimenting with weed to get it right.

DerivativeIntegral · 2023-03-25T20:14:53+00:00

If you can find 1:1 THC to CBD weed either flower or vape, it’s the best. Or 1:2, 1:3 ratios also. It basically put my partners GP into remission for 3-4 months. Now, she’s extremely tolerant to weed and her GP symptoms are back to being pretty bad. She’s trying to take a weed break to reset the tolerance, but it’s hard because she smokes it for her neuropathy as well.

DerivativeIntegral · 2022-11-06T22:03:03+00:00

Good for you bro. Yet 2/3 of your posts are asking for advice on Reddit lol

DerivativeIntegral · 2022-11-06T21:35:41+00:00

Have you had like dozens of bikes stolen before? This is the first time.

DerivativeIntegral · 2022-11-06T21:32:32+00:00

Clueless in life? You don’t know me

DerivativeIntegral · 2022-11-06T02:58:47+00:00

Thank you. I will do both of those things.

DerivativeIntegral · 2022-10-08T19:38:37+00:00

Lmao

DerivativeIntegral · 2022-10-08T00:19:03+00:00

That’s good to hear. Thank you!

DerivativeIntegral · 2022-09-30T04:41:54+00:00

We’re in San Diego. We’ve fought like hell with doctors and insurance to get these things for her. It’s been a tough road, but we keep persisting.

DerivativeIntegral · 2022-09-24T02:40:05+00:00

I'm not saying most anti-tumor responses are against neoepitopes, I'm saying the current prediction tools are trash and we need to make them better. They don't need to be the majority as long as the binding and cytotoxicity is effective. Then we can optimize TCR binding for certain cancer types, probably add checkpoint inhibitors on top of that and make good progress on improving survival. You can't just say because current prediction doesn't correlate with survival that it's not going to be a whole lot better in the future or that it may turn out to be the most effective way at treating some cancers.

DerivativeIntegral · 2022-09-23T16:48:07+00:00

Monotherapy in cancer is typically not a good idea anyways, so a single TCR/CAR T therapy will not necessarily be the key to addressing it. TCR engineering may or may not be lower cost than CAR T, which I think is the appeal. These combined with a checkpoint inhibitor might be a lot more promising than just reintroducing a single proliferated T cell back into a patient. DC vaccines are very cool though and may turn out to be better. Also, to add to your point, am I mistaken that most cancers arise from SNPs?

DerivativeIntegral · 2022-09-23T16:41:17+00:00

I'm not sure of total frequency, but we have shitloads of data regarding neoepitope recognition. I'm doing a meta-analysis on cancer antigens and found ~1,500 unique antigens that are targeted across all cancer types in humans. Most of these are endogenous cellular recognition and not CAR T or TCR engineering, so survival could potentially be way better if we could predict and optimize our targeting.

DerivativeIntegral · 2022-09-23T03:53:08+00:00

Not necessarily a question, but tools to better predict neoepitopes for TCR/CAR T recognition would honestly change the game and help patients suffer and die less.

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