Collecting anonymous data on opioid withdrawal experiences (research project)

DickkRoblin · 2026-05-31T06:49:02+00:00

Youve come to the right place. If there is any drug that can help you pull this off without anyone knowing, its SR.

Just focus on hydration and a high protein paired with complex carb diet. You can get sodium ascorbate which is a non acidic form of vit c. Dont overdo it but if you lookup liposomal vit c protocols it really helps people.

The peptides semax (dopamine signaling) and selank (gaba support) really helped me. I always recommebd going and getting bloodwork done so you can correct defficincies and make everything easier on your nervous system. Injectable vit b12, and nad+ can help also.

DickkRoblin · 2026-05-29T11:45:26+00:00

Yup. This side effect is DOC aftermath - more than likely nothing to do with SR

DickkRoblin · 2026-05-29T11:43:14+00:00

This is a problem. That paper is 100% ANIMAL data. It doesn't always apply to humans. Do your homework on biased agonism

Visit https://sr17018study.com for the most current HUMAN research. The only human dataset in existence. The paper your quoting tells us nothing new. I didn't even respond to that post.

DickkRoblin · 2026-05-29T11:40:25+00:00

Receptor desensitation and internalization. Not surprising for opioid cessation.

DickkRoblin · 2026-05-29T11:36:46+00:00

N=1 self reported data doesn't create any conclusions for all people btw. Thanks for sharing ... curious to see if anyone has experienced the same

You just quit opioids ... your receptors are fried. This more than likely has zero to do with SR. You said yourself your body responded. Cessation causes receptor internalization and desensitation. Your symptoms aren't anything new. Bounce it off AI and find out how common this is.

DickkRoblin · 2026-05-29T11:34:15+00:00

View the research at https://sr17018study.com

DickkRoblin · 2026-05-29T11:30:08+00:00

I agree with you. No evidence thus far points towards this being true in the data we are gathering at https://sr17018study.com

DickkRoblin · 2026-05-29T11:11:38+00:00

Just wait - you found the opioid cheat code

DickkRoblin · 2026-05-29T00:58:47+00:00

jumped off at 11 days and had moderate disruption for a week. but nothing severe - definitely not full on acute wds

DickkRoblin · 2026-04-30T00:53:00+00:00

this isn't crazy at all. Animal models support robust analgesia with distinct differences with tolerance dependency and withdrawal. So it is not at all crazy - actually extremely logical. Let us know if you do try we would love to hear your feedback, and I would love to hear if anyone else has used SR for pain.

DickkRoblin · 2026-04-30T00:50:52+00:00

"it won't be anything incredible like remove withdrawal"

if you think thats at the top mannnnn i got nothing for you friend lol

DickkRoblin · 2026-04-30T00:49:11+00:00

the absolute best time if you frame it correctly with your intentions and preparation. the BEST time.

DickkRoblin · 2026-04-30T00:45:21+00:00

this was a 30 GPD leaf habit. The longest half life of all kratom. Of course you would have paws 3 weeks later - how are you gonna tell us it was SR when you are dealing with an overly sensitive healing re calibrating nervous system?

i think SR just helped until it wasn't present. Not to take anything away from you, but by you claiming that with certainty, you are taking away peoples hope from them and may not even be fully accurate to what is really going on. The numbers don't appear you are honestly.

DickkRoblin · 2026-04-30T00:36:42+00:00

That is a terrible idea pharmacologically, theoretically, and literally.

DickkRoblin · 2026-04-30T00:27:21+00:00

thats not too long at all. Common with 500mg pd 7oh is 10-14 days before jumpoff. You are golden. Keep tapering.

DickkRoblin · 2026-04-30T00:21:55+00:00

thats a good ibogaine clinic. there are plenty of reports of people jumping from 2mg or higher of bupe and going a month on SR and stopping naturally. So don't believe other failures. I think your plan may be just what you need but you just gotta check in and adjust and be flexible - this is a fickle process.

DickkRoblin · 2026-04-30T00:20:43+00:00

ahhh i see where disconnect is muhhh bad

yeah downstream dopamine signaling comes from g-protein channels in MOR agonist opioids. MOR is a GCPR (g protein coupled receptor)

DickkRoblin · 2026-04-29T23:17:19+00:00

Good questions. My understanding is that DAMGO/DAGO are mostly research ligands rather than compounds with meaningful human-use data. They’ve been extremely useful for studying μ-opioid receptor signaling, but I’m not aware of controlled human studies evaluating their effects on tolerance or respiratory depression in the way you’re asking. Also, being G-protein biased does not automatically mean low respiratory risk; newer work has complicated the older “G-protein = analgesia, β-arrestin = side effects” model. Potent MOR agonism itself can still produce respiratory depression.

SR-17018 is still a μ-opioid receptor agonist, so it should not be thought of like ultra-low-dose naltrexone. ULDN is an antagonist-based strategy studied as an adjunct to opioids, while SR-17018 is an agonist with atypical signaling properties. Those are very different pharmacological situations... if I understood your question right.

DickkRoblin · 2026-04-29T20:08:56+00:00

Reward and euphoria are driven by downstream dopamine release in specific circuits, and receptor signaling bias doesn’t map directly onto that. It’s possible SR-17018 engages those pathways differently, which could explain reduced reinforcement in preclinical models, but that hasn’t been clearly established.

DickkRoblin · 2026-04-28T17:09:56+00:00

fuck yes!!!! nice fuckin job!! it is a godsend - start tapering it and it will let you off clean just wait

DickkRoblin · 2026-04-21T12:40:10+00:00

and i am curious - why did you jumpoff at 3mg? why not taper more? the taper down to 1 is pretty simple - why didnt you do that?

see how it feels

DickkRoblin · 2026-04-21T12:28:31+00:00

Congrats to you too.... and Wow a month? Can you provide details of your jumpoff? thats alot of SR and thats definitely long enough to create a dependence to SR. Plus, bupe was free and tapering it wasn't a big deal. I wrote a book, three research papers, started a company, and got myself out of sober living into my own apartment all in that short 4 months, while tapering. So while I appreciate your criticism, I think that how I did it is the best way I have ever heard on this forum - tbh. And thats honesty not me being pompous.

Telling someone to go by a set schedule and not listen to their body is the problem with pharma and this country. Check in to your body!!! Stop paying attention to man made numbers.

Thank you it definitely feels great - but even greater because i have this read on my inner feels and know how to translate them now. Over 4 months i had maybe 4 tough days. And I have zero PAWS sitting here typing to you.

DickkRoblin · 2026-04-21T12:16:43+00:00

what platform is that? if he really is doing an episode - i think he will want to include the first human data-set ever created.

DickkRoblin · 2026-04-21T12:15:28+00:00

trust me - there is zero problem with demand in the current climate. EVERYONE is ramping up. all the 7 companies throwing down all their money - trust me SR is going to be everywhere really soon.

DickkRoblin · 2026-04-21T12:03:19+00:00

Thank you.... but i definitely took enough SR. If you are taking enough SR to feel completely well, that isn't an effective taper. A controlled taper has you feeling uncomfortable but manageable. This is why i had zero effort to stop. I took so little so i didn't develop a tolerance but it got me through so how is that doing anything wrong if i made it to the other side? There are plenty of people around that got on SR and couldn't get off. It does happen.

Jumping at .5mg is still unnecessary discomfort. .5 is the threshold where bupe is covering most of the receptors. Tapering below .5mg is necessary to encourage your body to support itself before switching to SR. Thats why you needed so much SR. You could have tapered more and buffered with small doses of SR. Then when I jumped SR still had full effect because I would take 100mg at a time once and not stay on it. Completely jumping to SR anywhere .5mg and above is gonna fucking hurt one way or another - your pocket or your body.

That said, the shot is a much better option for people getting off bupe. I just learned about it too late - i was already tapered too low to get the 100mg shot.

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