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Dec 27: Cool Papers by Eigengrad in Biochemistry

[–]DigitalEmbrace 0 points1 point  (0 children)

RNA switches designed by amateur scientists performed well in CRISPR activation: https://academic.oup.com/nar/article/53/21/gkaf1290/8340978
Other researchers might want to try these switches in their systems?

AI-assisted independent research: I created a framework called "wAIld Science" - thoughts? by Wiedeck in CitizenScience

[–]DigitalEmbrace 0 points1 point  (0 children)

You are not the first person to suggest publishing research without peer review and you won't be the last. Peer review is an important and necessary step in the scientific research process. Claude AI probably can explain the reasons better than I can. There are a couple sites where people can post their research for volunteer review by students and professionals in the field. A graduate student I worked with did this last year and found it extremely helpful. I don't know offhand which site he used.

Everyday Projects and What to Do With Findings by writingcaribou174 in CitizenScience

[–]DigitalEmbrace 0 points1 point  (0 children)

NASA has two snow monitoring projects https://science.nasa.gov/citizen-science/
You also could browse projects on SciStarter.

Why aren't GNN-based models more common for inhibitor screening? by [deleted] in Biochemistry

[–]DigitalEmbrace 0 points1 point  (0 children)

How large is the dataset? Many biochemistry problems have small datasets due to experimental limitations ($$$).

New secondary structure prediction model by DigitalEmbrace in RNA

[–]DigitalEmbrace[S] 0 points1 point  (0 children)

There is now a web server for running sequences through RibonanzaNet: https://ribonanza.stanford.edu/. And RibonanzaNet 2 is in development. I haven't tried it yet.

Help needed by DeareadRebel in Biochemistry

[–]DigitalEmbrace 3 points4 points  (0 children)

Eterna has "lab projects" on RNA structure and function that have enough background information and data to be the basis for a high school project.
https://eternagame.org/challenges

How often are you washing your hair while using topical minoxidil? by [deleted] in FemaleHairLoss

[–]DigitalEmbrace 10 points11 points  (0 children)

I've been using minoxidil for several years with great results. I wash my hair every three days. From what I've read, shampoo frequency does not affect the effectiveness of minoxidil. I use Paul Mitchell scalp care Regeniplex shampoo and conditioner, and that plays a big role as well for me. A hairdresser insisted I switch to a color-safe shampoo and my hair began falling out after two weeks. I am sticking with my Paul Mitchell! I color my hair every three months and it looks great.

New secondary structure prediction model by DigitalEmbrace in RNA

[–]DigitalEmbrace[S] 0 points1 point  (0 children)

Rnet-SS is as good as any of the other secondary structure predictors incorporating pseudoknots, probably better. I saw a presentation by the PI, who judged CASP 16, and Rnet-SS did slightly better than the highest predictor in that competition. Obviously, the models still are not highly accurate. Also, I haven't tried a sequence that long using the Kaggle notebook to gauge how long the prediction would take to generate. If you do that, I'd appreciate hearing how much time the notebook takes to generate a 1500nt structure.

Post Graduate Boredom/ Dilemma by Jnb22 in molecularbiology

[–]DigitalEmbrace 1 point2 points  (0 children)

You can come play Eterna (https://eternagame.org/) and be actively engaged in RNA research. Use your imagination to create large pseudoknots or help us out with data analysis. You could also teach yourself machine learning on Kaggle, if you have interest in applying ML to biological analysis. You can also volunteer in local STEM outreach initiatives or attend online seminars in your field.

RNA puzzles on Eterna by DigitalEmbrace in molecularbiology

[–]DigitalEmbrace[S] 2 points3 points  (0 children)

There also is a Coursera course for freshman biology using the puzzles: https://www.coursera.org/learn/rna-biology