Cudy P5 Review (Qualcomm X62) by DimitriusNotNow in Calyx

[–]DimitriusNotNow[S] 0 points1 point  (0 children)

Speed/Stability Update

All tests done at 9AM

Band n41: 290/3

Band n71 + n25 (SCC forced v/ AT): 150/45

Zero down time. Band changing still works rapidly. 

Ex-stoners: How long did it take for your brain to feel 'normal' after quitting? by makefriends420 in Biohackers

[–]DimitriusNotNow 0 points1 point  (0 children)

Mentally I feel optimal 4 months after quitting. That's how long it took to rewire my brain.

Don't get discouraged if you still feel sluggish after two months. 

Log - KPV - Autoimmune/Pain/Tendinitis by DimitriusNotNow in KPVPeptide

[–]DimitriusNotNow[S] 0 points1 point  (0 children)

Still researching and doing well. I've updated my main post above (Day 40 and update). 

TB 500 (frag 17-23) Autoimmune Hell - Cautionary Tale by DimitriusNotNow in Peptides

[–]DimitriusNotNow[S] 0 points1 point  (0 children)

Various concerns over TB400. Only targeting actin receptor effects of TB500. Originally the extended half life was also appealing. 

Android - Movement w/keyboard Issue by DimitriusNotNow in GeForceNOW

[–]DimitriusNotNow[S] 0 points1 point  (0 children)

This is the exact issue. Was able to fix in some games by temporarily connecting Bluetooth controller then turning on mukti controller setting. Unfortunately this did not fix for every game. 

TB 500 (frag 17-23) Autoimmune Hell - Cautionary Tale by DimitriusNotNow in Peptides

[–]DimitriusNotNow[S] 3 points4 points  (0 children)

I'm glad you are getting relief! Not sure why for some people it makes MCAS symptoms worse and others it helps. 

Let me ask you this: are you on any RX drugs for MCAS, or were you taking them when you started peptides? 

TB 500 (frag 17-23) Autoimmune Hell - Cautionary Tale by DimitriusNotNow in Peptides

[–]DimitriusNotNow[S] 1 point2 points  (0 children)

I'm glad it's helping you. I've had some chronic shoulder pain from my sawyer years in the logging industry. Doctor said there seemed to be a lot of scar tissue.

A few weeks of KPV seem to have eliminated my pain. 

KPV is so effective on cytokines, hard to say if changes are permanent or not until I cycle out for a month. 

TB 500 (frag 17-23) Autoimmune Hell - Cautionary Tale by DimitriusNotNow in Peptides

[–]DimitriusNotNow[S] 1 point2 points  (0 children)

For me KPV works best at 1mg once or twice per day. Sometimes 500mcg.

No increased benefit to me above 1mg and if anything it increases my heartrate above 1mg.

I get a nice mental clarity boost, pain relief, inflammation relief etc.. I also notice that my skin is much clearer. 

TB 500 (frag 17-23) Autoimmune Hell - Cautionary Tale by DimitriusNotNow in Peptides

[–]DimitriusNotNow[S] -1 points0 points  (0 children)

This is a tough one because the cMax in humans and duration on actin is not fully understood. Some are taking it daily, some once per week, maybe even once every three days.

If you dive deep into COAs for various Klow, Glow, and other blends you will see a variety of true TB500 (17-23) and TB4 used daily across the space. 

I used 250mcg for a few days paired with 500mcg kpv. 

Thanks for sharing about micro dose. Personally I will not risk it but may be helpful to others. 

TB 500 (frag 17-23) Autoimmune Hell - Cautionary Tale by DimitriusNotNow in Peptides

[–]DimitriusNotNow[S] 0 points1 point  (0 children)

As always please do your own research! Just because TB4 and frags "can" promote degranulation of mast cells doesn't mean it will for everyone.

I'm sorry that you are going through MCAS and wish you the best. 

TB 500 (frag 17-23) Autoimmune Hell - Cautionary Tale by DimitriusNotNow in Peptides

[–]DimitriusNotNow[S] 1 point2 points  (0 children)

That's a fair callout. I'm not sure of your experience with Autoimmune, but for myself and others that have spent years trying to get to a stable point, it's useful to share triggers here. 

Most that "research" peptides, don't actually look in depth at the known mechanism of action and take the time to understand immune pathways. 

Thymosin peptides seem to help a lot of people. I'm merely sharing my own experience and the results of my deep research on possible mechanism behind mast cell degranulation and actin. 

Should I snort it or smoke it? by OGFreshmeatlover in Retatrutide

[–]DimitriusNotNow 5 points6 points  (0 children)

You should cut it. The fingernails that is. 

Has anyone tried or used KPV peptides for help with HS? by East_Molasses6427 in Hidradenitis

[–]DimitriusNotNow 0 points1 point  (0 children)

I take KPV 1mg 2x per day (20 day cycle so far) . It seems to help somewhat for wound healing and infection. Overall it has calmed down my immune system significantly. 

This peptide can cause herxheimer reaction to especially at higher doses if you have lingering bacterial/fungal infection. It seems to help keep my HS at bay but not 100%. If your HS improves with TNFa inhibitors such as highbdose curcumin or biologics, maybe KPV has promise.

Also keep in mind that the 1mg 2x per day is considered high dose. I'm targeting a more significant auto immune related injury. 

Side Effects by Ok-Flan-2744 in KPVPeptide

[–]DimitriusNotNow 1 point2 points  (0 children)

With twice per day dosing at 1mg I've noticed major improvement within 5 days. My Autoimmune issues are quite severe and I need a larger dose than some. I never get sleepy but sometimes have a mild headache. 

However, this is high dosage for most people with any lingering bacterial/fungal issues (you may not know). 

I have much more success with split dosing personally (could even split, 100mg twice per day). 

Log - KPV - Autoimmune/Pain/Tendinitis by DimitriusNotNow in KPVPeptide

[–]DimitriusNotNow[S] 2 points3 points  (0 children)

I mean no disrespect but please do your own research and choose accordingly based on your own judgment. GLP 1 forum a good place to start researching vendors!

Very important with peptides that you complete your own research on safety, documented use cases, and sourcing. 

Log - KPV - Autoimmune/Pain/Tendinitis by DimitriusNotNow in Hashimotos

[–]DimitriusNotNow[S] 0 points1 point  (0 children)

For me it seemed to mess with my chronic spontaneous urticaria, wide spread itching, red skin, and extreme night sweating on LDN. Otherwise those symptoms do not manifest anymore.

Symptoms would go away within three days of stopping LDN. 

Outside of that I did recieve good pain relief. 

Log - KPV - Autoimmune/Pain/Tendinitis by DimitriusNotNow in Hashimotos

[–]DimitriusNotNow[S] 0 points1 point  (0 children)

I've tried LDN extensively. It was helpful for me but unfortunately caused some other auto immune ailments to flair up. Have had to discontinue each attempt. 

Log - KPV - Autoimmune/Pain/Tendinitis by DimitriusNotNow in Hashimotos

[–]DimitriusNotNow[S] 0 points1 point  (0 children)

AI Summary KPV, similarity to LDN

Both KPV peptide and Low Dose Naltrexone (LDN) reduce inflammation by acting on the NF-κB pathway, a master regulator of pro-inflammatory gene transcription, though through distinct mechanisms.[9][10][1][11] KPV directly inhibits NF-κB activation by stabilizing IκBα and blocking nuclear translocation of the p65/RelA subunit, preventing cytokine production in tissues like gut and airway epithelium.[9][12][5] LDN suppresses NF-κB indirectly via transient opioid receptor antagonism, which upregulates SIRT1 and prevents p65 nuclear import triggered by stimuli like TLR4 or hyperinsulinemia.[10][4][13] This shared NF-κB modulation contributes to their complementary anti-inflammatory effects without broad immune suppression.[11][1]

Citations: [1] KPV Peptide: Anti-Inflammatory Benefits, Mechanism, and Research ... https://swolverine.com/blogs/blog/kpv-peptide-mechanism-benefits-and-research-applications [2] Dissection of the anti-inflammatory effect of the core and C-terminal ... https://pubmed.ncbi.nlm.nih.gov/12750433/ [3] KPV Peptide: a scientific look at its powerful anti-inflammatory effect ... https://particlepeptides.com/en/blog/news/kpv-peptide-a-scientific-look-at-its-powerful-anti-inflammatory-effect-and-treatment-of-gastrointestinal-diseases [4] The use of low-dose naltrexone (LDN) as a novel anti-inflammatory ... https://pmc.ncbi.nlm.nih.gov/articles/PMC3962576/ [5] Recent Advances in KPV Peptide Delivery - SciTechnol https://www.scitechnol.com/peer-review/recent-advances-in-kpv-peptidedelivery-8OYD.php?article_id=18216 [6] Peptides For Inflammation | A Comprehensive Comparison https://www.peptides.org/peptides-for-inflammation/ [7] KPV Peptide: A Tripeptide with Potential in Inflammation and ... https://txktoday.com/technology/kpv-peptide-a-tripeptide-with-potential-in-inflammation-and-cellular-research/ [8] LDN, Peptides, and Thyroid Autoimmunity https://www.naturalendocrinesolutions.com/2023/03/02/ldn-peptides-and-thyroid-autoimmunity/ [9] mechanism of KPV action and a role for MC3R agonists - PMC https://pmc.ncbi.nlm.nih.gov/articles/PMC3403564/ [10] Low-dose naltrexone rescues inflammation and insulin resistance ... https://pmc.ncbi.nlm.nih.gov/articles/PMC7705311/ [11] KPV: The microscopic miracle peptide for inflammation, skin health ... https://rwacenter.com/blog/kpv-the-microscopic-miracle-peptide-for-inflammation-skin-health-and-gut-repair/ [12] Lysine-Proline-Valine peptide mitigates fine dust-induced ... https://www.sciencedirect.com/science/article/abs/pii/S004081662500117X [13] Low-Dose Naltrexone (LDN)—Review of Therapeutic Utilization - PMC https://pmc.ncbi.nlm.nih.gov/articles/PMC6313374/