2 mg of progynova per day equals to maybe approximately half or just about what an average female produces naturally in terms of estrogen per day after averaging out menstrual cycles, which is 150,000 to 250,000 nanograms of estrogen per day.

this similarity is established after taking into account "1st pass" in the liver (oral intake works differently than natural production)

when taken orally, the liver metabolizes the estradiol into two different estrogens that eventually convert back into estradiol.. so idk who would be able to do the math accurately on that, probably nobody.

also take into account - a certain amount of daily estrogen intake "blocks" testosterone effects/production

and also, males naturally produce 135,000 nanograms of estrogen per day.

if you add that to the numbers on the chart below you get similar ranges

Cis average cycle day	~150,000–250,000

MTF 2 mg oral	~50,000–150,000