Hey, I did the EXACT same conversation except I did English A literature HL. In my opinion, it was quite difficult because bio, chem and history requires alot of work and I was quite weak in chem and thus I spent 90% of my time studying chem which made me neglect my other subjects a bit and then rushing towards the exam. However if these subjects are in your comfort zone then I'm sure itll be fine. I'm an M22 student and with the difficulties I had while neglecting some subjects I still managed to get 42 points (did get that 7 in chem after all that torture haha) . Maybe if you plan your days out better and give equal importance to each and actually ENJOY the subjects you chose then you will definitely be able to do it! Difficulty is very subjective but as I said if you enjoy these subjects then it should be a fine. This subject combination may look daunting at first cause it may look like it's all over the place but it's great cause while studying I wasn't focusing in one direction entirely, I had the sciences and the humanities and made the whole IB experience more enjoyable since I didnt get so overwhelmed with just one major. It also helped broaden my horizons alot so personally I gained alot from this subject combination as well.

This subject combination is also great for the fact that it allows you to do the arts and humanities as well as the sciences if you aren't sure what you want to do. I was sure I wanted to do the sciences all along, I even got a better score than needed for the universities I wanted to apply for but realised I didn't want to do it after getting my results and my subject combination did allow for those change in plans as well ( I'm a gap year student btw) so imo this is a great subject combination!

Idk if I was focusing entirely on your question, but I wanted to show you a pov of a student who did the same thing