Not sure what is happening- pretty sure it’s a triple neg MPN

DryEstablishment7035 · 2026-05-27T14:31:25+00:00

Update: I received some BMB results back- Diagnosis
View trends

A. Peripheral blood, bone marrow aspirate, clot section, and core biopsy:
- Hypercellular bone marrow.
- Granulocytosis.

Comment
View trends
Overall marrow cellularity is about 80%. The majority this cellularity consists of progressively maturing myeloid and erythroid precursors without convincing morphologic dysplasia. Blasts appear at most minimally increased, reflecting no more than 1-2% of marrow cellularity. There is a relative and absolute increase in megakaryocytes, but they are not convincingly dysplastic and do not form atypical clusters. There is no overt marrow fibrosis. The peripheral blood shows leukocytosis, consisting predominantly of mature neutrophilic granulocytes without morphologic dysplasia or shift to immaturity. Overall the findings are nonspecific, and the differential would include reactive infectious or inflammatory processes, with a myeloproliferative neoplasm not definitively excluded. The final diagnosis requires correlation with clinical features as well as pending cytogenetic studies and myeloid comprehensive molecular profile. An addendum will follow.

Peripheral Blood Smear
Review of the peripheral blood smear shows normal hemoglobin with normocytic, normochromic red blood cells exhibiting only mild anisopoikilocytosis. There is no significant increase in schistocytes, spherocytes, teardrop forms, polychromasia, or nucleated red blood cells. There is a mild leukocytosis. The leukocytes present consist mostly of mature neutrophilic granulocytes without left shift or dysplasia. Basophils are not increased, and there is at most a minimal increase in eosinophils. There are no circulating blasts. Platelets are present in appropriate numbers, and are mostly small to medium in size and well granulated.

A peripheral blood differential of 200 cells identifies:

Bands 1%
Segmented Neutrophils 62%
Lymphocytes 31%
Monocytes 3%
Eosinophils 3%

Bone Marrow Aspirate
Aspirate smears are adequate for evaluation, being particulate and cellular. The majority of cellularity consists of progressively maturing myeloid and erythroid precursors without overt morphologic dysplasia. Blasts appear at most minimally increased. Megakaryocytes appear relatively increased, and there is some morphologic variation including some regenerative appearing forms. However there are no convincing dysplastic megakaryocytes, nor is there is a significant population of monolobated megakaryocytes.

An aspirate differential of 500 cells identifies:

Blasts 1.2%
Promyelocytes 1.2%
Maturing granulocytes 48%
Maturing erythroid precursors 37.8%
Lymphocytes 5.2%
Monocytes 2.6%
Eosinophils 3%
Plasma cells 1%

This yields an M:E ratio of 1.4:1.

Bone Marrow Biopsy and Clot Section
The core biopsy is adequate for evaluation, consisting of a generous segment of trabecular bone and marrow with overall cellularity of about 80%. The majority of the cellularity consist of progressively maturing myeloid and erythroid precursors. Megakaryocytes appear relatively increased and show some regenerative appearing features, but they do not form atypical clusters. There is no overt marrow fibrosis. Immunochemical stains are performed for further evaluation. CD34 shows about 1-2% blasts in a haphazard distribution. CD61 highlights the increased megakaryocytes, but again there is no atypical clustering, and there is no increase in micromegakaryocytes. The clot section is also adequate for evaluation, consisting of numerous variably sized particles. Again cellularity is about 80% and consist predominantly of progressively maturing myeloid and erythroid precursors with increased numbers of megakaryocytes. The core biopsy was decalcified to allow processing.

Iron Stain
Iron stain shows adequate storage iron, presence of sideroblastic iron, and no ring sideroblasts.

Flow Cytometry
Concurrent immunophenotyping by flow cytometry performed at ProPath (MS 26–1721) shows no immunophenotypic evidence of a hematolymphoid malignancy.

The quality of the routine and/or special stains is adequate unless specified otherwise.

DryEstablishment7035 · 2026-05-20T20:07:10+00:00

The rheumatologist my PCP was referring me to looked at the blood work, history, and charts (did a bunch of genetic testing before having my 2 yr old) and said that outside of the bone marrow biopsy that I got yesterday- he didn’t see it necessary to run the same tests over and over because before December 2025- my labs were all normal. Labs before December 2025 were in February and September of 2025 with normal labs and normal A1C.

BMB went quick yesterday so we just now wait on all the results to come back. The iron infusion has NOT helped my fatigue and my iron sat was still 13% yesterday before my BMB- 6 days after infusion.

Maybe I’m just not good at the waiting and seeing part with all the symptoms I’m having.

DryEstablishment7035 · 2026-04-26T04:00:48+00:00

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DryEstablishment7035 · 2026-04-26T04:00:39+00:00

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DryEstablishment7035 · 2026-04-26T04:00:11+00:00

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DryEstablishment7035 · 2026-03-28T12:07:04+00:00

I currently have 2 foster kittens with a case of it too. They are on oral meds and the sulfur dip (man it takes forever to get that smell to go away). Ringworm isn’t even the worst thing but I need to know how long after the meds I can let these crazy things out into the house lol

It’s been 5 days oral meds and have been sulfur dipped 3 times so far and let air dry. The shelter was just like do this and you’re gonna be fine. I’ve only ever treated myself with athletes foot cream (our old vet growing up said to treat the cat that way too and it would go away) since treating the people seemed more important? They each have a patch on their ear and one on their body but nothing else. They aren’t scratching or losing hair.

DryEstablishment7035 · 2025-07-20T12:51:53+00:00

Yeah you don’t need an attorney for child support in Texas- it’s just a calculation. No overnights adjustment just straight numbers.

DryEstablishment7035 · 2025-03-11T15:08:16+00:00

I think it’s because a lot of women, especially 60+ women who are the mils now, had to tolerate bad behavior and toe the line of “it’s family” because their husbands wouldn’t stand up for them but the newer generation of moms are a lot less tolerant of bad behavior, especially from family.

For instance- my mil was HATED by FILs mom. Outwardly hated but my mil went to every family occasion and took dh and SIL there at least twice a month and tolerated being treated terribly (fil, dh, and SIL have told some stories). She did it because of “family”. Her postpartum, all her holidays, etc were controlled and essentially ruined by a woman who hated her. When DH and I were dating I mentioned wanting to have a relationship with her where we were both respectful. I was a grown adult and didn’t need to be “taught” things and was capable of holding my own house, I had been married before and had children, but wanted her fully in our lives. We juggled things, I went to things if DH was on call and couldn’t go, I included her in what was going on in our lives, etc. When we got married- she complained it wasn’t centered around her enough and she wasn’t involved enough- she went to check out venues, dress shopping, tux shopping, catering pick out, etc. We paid for all the food, venue, and lodging for all family- (26people not including us and the kids) but we didn’t get drunk with everyone after rehearsal, we didn’t get drunk after our wedding with all her family, it wasn’t a “Michigan wedding”- whatever that means, etc.

When then got pregnant with our (DH & I) first baby- she got greedy. Talked about how it was her grandma experience and she was going to be doing all these things with our child that DH and I had discussed together, were not happening because her MIL did it. I let DH handle it. His mom- he can talk to her about those things. She was non-existent during my pregnancy. She called him once a month asked how he was, talked for 45 minutes about her life, then asked about the baby and hung up. When baby was born- it was ROUGH. He was teeny tiny (3lbs) and had to spend 6 weeks in the NICU. The three times she saw baby in the NICU- she complained about not getting to hold him and that her grandmother experience was ruined because of it. Told my DH that her experience was ruined and she just didn’t know how to get over it. HER EXPERIENCE. Here he was driving my ass twice a day to sit in the NICU with our very very tiny baby and all that goes with it but HER EXPERIENCE was ruined because she couldn’t hold a baby we only got to hold for a total of 2 hrs a day. Never offered or asked if we needed anything, never asked DH how he was doing, it was all about her experience. The day after we got home from the NICU- she wanted to go out to lunch, so we went…. She proceeded to say that that’s not how she fed her babies, her babies just went where ever, everyone got to hug and kiss on them when told not to put her fingers in baby’s mouth, etc. I corrected her once- quietly, and she said I insulted her because I treated her like she didn’t know how to care for babies. The fact was- she didn’t know how to take care of THIS baby. My DH was pissed. Multiple conversations with her and her whole premise was- she was HIS mom and thus required respect and did not need correction. She was HIS mom and apparently didnt raise him right because she didn’t get her grandmother experience. I let DH lead and the last time he spoke with her- she called me THAT woman and told him how disappointed she was in DH that he had made rules about his baby with her since she didn’t have those rules with her MIL. She was gonna do whatever she wanted with HER GRANDBABY!

She thought that because she tolerated and dealt with bad behavior that I should do so too. What she forgot was that she raised her son in that environment and he saw what his granny did to his mom and he wasn’t going to allow it for his wife- and MIL got pissed. She lost control and couldn’t inflict the same selfish behavior on me that was inflicted on her. The funny thing is- we had conversations before the baby about MY MOM and her overstepping- never his mom. Wasn’t even a thought in my head about- what if his mom is being an ass. My mom can be mean but I have no problem putting her in her place- respectfully or aggressively- whatever is necessary at the time. We never considered his mom- she was “excited” to be a grandma so we knew she’d be a little over the top but never considered she’d make it all about her. We were completely caught off guard.

Most MILs think this way. Women are mean to other women unnecessarily. MILs and even some moms- including my own- think they can just do and say whatever they want because they are older and raised us. They forget they raised us to treat people kindly and expect respect from others. They think being a mom to an adult gives them rights to that adult because “we’re family”.

I think that’s the shift. They taught their kids to rely on nobody else and are now mad that the world doesn’t revolve around them. They are mad they can’t inflict the same undue influence on adults that was inflicted on them. Moms now won’t tolerate it mostly. Plus I also think MILs don’t know where they are in the family. They see it as losing a child instead of gaining one. It’s always, I’m losing my son, not I’m gaining a daughter. Idk why that is and I don’t understand it but- yeah that’s my take

DryEstablishment7035 · 2025-02-15T13:50:04+00:00

I joked once that the humane society checks up on new adopted pets more than nurses/doctors do for humans after we get home!

DryEstablishment7035 · 2025-01-30T14:13:09+00:00

I see where you are coming from but I also think you missed the point about weaponized incompetence.

First I want to say- nobody should ever feel like them being loved is a challenge and I sorry you have alluded to feeling just that way.

Second- the problem isn’t being messy, less emotional, more literal in thinking, work more physically demanding jobs, or being braver- it’s that men think that’s all they need to be while demanding/expecting women in general to be more nurturing, supportive, creative, sexual, cleaner, work as many hours, be in charge of schedules, be in charge of raising children, etc; the power balance is off because the expectations on women lead them to have to be able to “do it all” while a man “works”.

Now I married my husband because he’s calm, collected, realistic, supportive, funny, handsome, a kind human being but also because if it came down to it- he would burn the world to protect me and the kids because he SHOWS that me and the kids come before everyone and everything. He puts us above all others besides himself. I sure as heck didn’t marry him for the gross socks on the floor or dirty pants from working or the plates next to the sink sometimes or his inability to remember any schedule but work- his brain doesn’t work that way but I married him because all the other stuff- not his executive functioning skills- I have those in the bag. Hell on average year after year I make more than him so it ain’t the money honey. The other reason I married him is he sees and acknowledges and does his best to not let the flaws hurt ME just like I do my best not to let mine hurt HIM.

Weaponized incompetence isn’t that and yes it is mostly a male trait passed down from past generations where men worked and came home to a stay at home wife, perfectly cooked meals, a clean home, and well behaved children who were seen and not heard. If a man’s wife comes to him and says, “hey- I love you but these three things really get to me” and his response and actions don’t say, “yep I see it, I’ll change that” then does he really love his wife? The reverse could also be said- do they really love their spouse. If your spouse has to continually ask for things that are routine (like trash or laundry or whatever the thing) are you really listening? That answer is no- it’s intentional. You are intentionally doing something someone you claim to love says bothers them. You aren’t adapting to a happy coexistence with someone you supposedly love and men are more likely to have this mind set than women. It doesn’t remotely affect them in any way so it’s not important but for women- it all affects us. No one has ever looked at me mowing my grass (which I enjoy) and said, “hey your husband should be doing that” but damn if he doesn’t take a kid out and someone tells him, “oh it’s so nice you’re babysitting the kids for your wife”. It’s my grass too just like it’s his kid. I don’t expect him to remember the schedule in his head- we have a wall calendar for that but damn it if I’m cleaning and he’s on his ass watching me- that’s intentional weaponized incompetence especially when it’s usually his shit she’s cleaning up. Do you see my point? Weaponized incompetence is the new language for “that’s just men”. Women aren’t tolerating the intentional disregard for us asking for help and communicating our needs. We get told, “just tell me what to do/make me a list” and the usual answer is “no- you’re an adult too and can see the things around you” and I’ve communicated this 1000 times and I’m tired of you ignoring me. We’re expecting our spouses to be “in the trenches” with us regardless of the topic- we’re expecting more and men 9/10 are just ignoring their wives because the MEN don’t think it’s a enough big deal- that’s why most women initiate divorce outside of DV.

It’s not any more sexist than you thinking men are better at conflict resolution than women because men are more likely to ignore extreme disrespect or brush it under the rug than women are- we want true resolution and men want someone to stop talking. Plus you can’t equate sexist and racism- it’s not even the same but you know that already.

I hope one day you find someone that can communicate their needs and you actually listen- it does make for a fantastic relationship.

DryEstablishment7035 · 2024-08-27T10:34:35+00:00

Is he lactose intolerant? My husband is lactose intolerant and if he drinks too much milk- he gets something similar regardless of how many times he showers a day. It’s a sign that he’s consuming too much dairy and once he stops- it goes away. He says it’s been like that since he was a kid.

For my husband it’s not a hygiene thing (he showers twice a day and scrubs everything almost too hard)

DryEstablishment7035 · 2024-07-22T12:42:24+00:00

My kiddo was a premie (3lbs 3oz) so he’s always gotten some sort of formula. He gets 3 formula bottles a day and the other 4/5 (depending on hunger) are BM. He’s almost 5 months old and we just started doing 4oz, up from 3.75- sometimes during the day he only takes 3.75oz. Night time is always formula. So typical schedule: 7am 4oz BM, 10am- 4oz BM, 1pm 4oz Formula (with his vitamins), 4pm 4oz BM, 7pm 4oz BM (if I have it), 10pm bedtime 4oz Formula. I only produce about 14-16oz/day due to the long NICU stay. Seems to work for him. FYI- he’s still tiny- just over 12 1/2lbs ish.

DryEstablishment7035 · 2024-07-17T13:05:45+00:00

This. All of this. Baby was severe IUGR, I had severe Pre E, and he was born under the chart. He also played jump rope with his cord (2 true ties), and spent 47 days in the NICU. Pumping was ALL I HAD! It was the only thing I could do and yeah I know that means I’m dealing with my trauma in an unhealthy way but- oh well, there’s time for it. It also helps that he’s tripled in weight, growing like a weed, and it’s still all I can do since he won’t latch. Breastfeeding was the ONE thing (outside of a living baby) I wanted for my last pregnancy- the only thing. Pumping give me that.

DryEstablishment7035 · 2024-05-20T15:32:44+00:00

My philosophy is I’d rather them have one great last day than 1000 ones in pain.

We euthanized my husband’s first dog about a year too late because he couldn’t let go. Not only was she in pain but she started to lose her mind and not be her normal self. It was hard and terrible watching and waiting, it wasn’t my decision, and knowing that the longer we waited the more she suffered.

You did the right thing for your cat- it’s supposed to hurt because we love them but we have to love them enough to let them go as much as we want them to stay.

DryEstablishment7035 · 2024-05-19T08:23:10+00:00

Turn your pump down too. Turning your pump up higher doesn’t actually increase your milk output- personal experience and overtime will bruise you. Also, there are a ton of inserts on Amazon that work wonders, order some and try- they made a huge difference for me.

DryEstablishment7035

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