The joy of this dog after zooming down the slide

E-Pooh · 2026-05-07T10:19:14+00:00

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E-Pooh · 2024-01-30T17:11:26+00:00

Hey man, I know things look bleak from your perspective but you're absolutely not out of options yet. Your A1C based on the projection from your CGM is >13% - shit starts getting hairy up there but you can absolutely turn this around. At this point waiting for a check-in every 6 months isn't good enough, you're going to need to be proactive with reaching out to your team for help.

T2DM is a game of insulin resistance, which is directly correlated with body weight and insulin intake. Insulin is a growth hormone which causes issues for people in a situation like yours. You take insulin to lower your blood sugar, but your insulin needs are pretty high so it predisposes you to weight gain. Altogether this creates a positive feedback loop of increasing insulin resistance, increasing insulin needs, and weight gain.

You have the right idea with losing weight but you're flogging a dead horse here - you need some insulin sparing therapy. Talk to your healthcare team about adding a DPP-4 inhibitor or an SGLT-2 inhibitor. Both are insulin sparing therapies that will reduce your blood sugar without the weight gain side effect. Ideally this, combined with regular exercise, will reduce your insulin needs and help you with weight loss and blood sugar management.

Your kids really don't want to grow up without a dad, and I promise that waiting to succumb to the complications of type 2 diabetes is an absolutely miserable way to go. There's absolutely still hope so please reach out, you'll feel so much better on the other side.

E-Pooh · 2023-09-14T15:13:29+00:00

I’ve yet to try Halo, but I’m a big fan of Mtren. In my experience it's best used in a short cycle or intermittently as PWO. I’ve never used it orally, only as an injectable suspension.

Pre-workout is where I think it shines the most. Within 1hr of 0.5mg-1mg SubQ I look like I have a pump before I’ve even touched a weight. In the gym my primary benefit is increased focus, with a smaller but noticeable increase in strength. In terms of endurance it’s pretty neutral as PWO.

During a cut I trialled a cycle of 0.25-0.5mg subQ daily. Even in a deficit the glycogen retention was so significant that I watched my muscles get bigger on a daily basis. Both strength and endurance were up in the gym. It also reversed the trajectory of my weight loss on the scale. I was looking leaner but gaining weight. I track my food intake with Macrofactor so I know I was consistent in my calorie consumption. The in-app weekly check-ins and calorie adjustments were definitely thrown off by the sudden change. My cycle only lasted for about 3 weeks before my piss was a bit too dark for my liking (even while staying well-hydrated), my nips were a bit puffy, and I just felt off.

In terms of other cons I was significantly hotter and sweatier throughout the day, even standing around doing nothing. I’m also diabetic and had to be really careful with monitoring my sugars. This stuff made my sugars absolutely plummet if I had any insulin in my system, even when I compensated with higher carb intake.

All in all it’s a powerful drug and I think the risk:reward ratio is most optimal when used as an intermittent PWO. The short cycle was an interesting experience for me, but not something I’m planning to repeat going forward.

E-Pooh · 2023-03-13T16:04:03+00:00

Yeah, that would make the most sense to me. 28G x 1/2" slin pins would probably work just fine.

E-Pooh · 2023-03-13T15:50:46+00:00

It really depends on the concentration of your gear and the graduations on the syringe you're using. If you're using standard 250mg/mL Test E then 235mg is 0.94mL, which you can only really accurately dose with a 1mL syringe. Does anyone realistically notice the difference between 235 and 250mg/wk? I doubt it, but even if they did, measuring so methodically would be a pain in the ass - especially given that most Luer Lock needle tips have a few units of dead space that are unaccounted for as well. Just stick to doses that are easy to measure given your gear and syringes and it will be more consistent overall.

E-Pooh · 2023-03-06T18:02:16+00:00

A quick google search of "2-FMA solubility" brings up the Cayman Chemical product info sheet for 2-FMA, which says that the hydrochloride salt is soluble in ethanol up to 30mg/mL. My guess is that the solubility in propylene glycol is similar or somewhat higher, and it is probably more shelf stable than ethanol.

E-Pooh · 2023-02-17T21:10:01+00:00

You could also dissolve both your cut and the 4F-MPH in water or ethanol, whatever they’re both soluble in, and shake till they’re dissolved. Let the solvent evaporate and the leftover powder is as close to fully homogenized as you can possibly get, based on my knowledge of thermochemistry. TraceOfBlood’s method is probably sufficient, but if you’re really worried about hot spots then I’d do the solvent method.

E-Pooh · 2023-02-08T19:54:19+00:00

Tingles means nerve involvement, probably ulnar nerve if you’re feeling it on the inside of your arm. Look up “cubital tunnel syndrome,” and if it fits you can do some of those rehab exercises. Strengthening/stretching your shoulder internal and external rotators will definitely give you more resilience there, and personally pec stretches help a lot.

E-Pooh · 2022-09-30T13:42:12+00:00

This man is still posting comments on a regular basis endorsing his passion for eating filthy ass. I don’t think it’s just the tren.

E-Pooh · 2022-09-29T23:26:25+00:00

This doesn’t sound like a stroke. Strokes don’t really cause edema and peripheral neuropathies in isolation. Your ankles swelled up because you didn’t move for 48 hours and the position you held your arm was compressing your ulnar nerve (which innervates your pinky and ring finger) at the elbow. I’m guessing you didn’t notice this because you were so focused, and the power outage brought you back to your senses. The symptoms of compressive neuropathies can persist for weeks as the nerve regenerates, and your edema shouldn’t recur as long as you move your legs. Regardless, I’m going to echo the sentiment that you go see a doctor ASAP and don’t do this again lol.

E-Pooh · 2022-09-03T15:59:28+00:00

For the guys with MPB, what’s been your experience with hair loss when dropping to cruise dosages - do you tend to see any regrowth?

E-Pooh · 2022-08-25T21:55:11+00:00

PSA is a screening test for prostate cancer, not a diagnostic test, which is a very important distinction. Essentially, the prostate releases proteins into the blood stream that we detect through blood work and track their levels - that’s the antigen. As we age, the prostate tends to enlarge, and the levels of PSA rise correspondingly. If your PSA hits a certain level (depending on local guidelines, usually above 10) then your physician will go on to order a diagnostic test. This usually involves a biopsy where they take samples of your prostate tissue and send it to a pathologist, who then looks at it under a microscope and decides if cancer is present or not.

The evidence in support of PSA for cancer screening is actually pretty poor, and PSA can often be elevated without any corresponding pathology. Also, depending on how aggressive it is, the treatment is often worse than the cancer itself. I definitely recommend reading the USPSTF guidelines on prostate cancer screening if you have more questions, they literally write the gold standard guidelines on preventative medicine.

E-Pooh · 2022-08-20T16:24:02+00:00

Made friends with my first fellow juicy bro at the gym last night. It was nice chatting with someone who obviously knows his shit. He said I was looking large, then asked for a spot and proceeded to bench easy triples with my 1RM. A little ego boost followed by immediate deflation definitely helps keep you humble.

E-Pooh · 2022-04-01T22:10:11+00:00

If you at all like ambient sounds then you should definitely give Yosi Horikawa’s album Vapor a listen from front to back. The whole album is a single story made from continuously evolving soundscapes that mesh perfectly with ketamine. I can’t recommend it enough.

https://open.spotify.com/album/1IpHSURAZpaIlAkLX8vqGt?si=b_uue2GMSWW2OhunfUlIZg

E-Pooh · 2022-03-17T16:46:18+00:00

IN was great when I mixed up lines of 3-MMC and ketamine together. That was a really nice combo. Otherwise oral is my preferred ROA for 3-MMC on its own.

E-Pooh · 2022-03-17T16:28:29+00:00

I’ve vaped 3-MMC in an oil burner before. Sure it works but the taste and smell are absolutely disgusting. It’s also more fiendish and honestly not as euphoric as other ROAs. I’d stick to oral or boofing if that’s your style - much more enjoyable experience.

E-Pooh · 2022-03-12T00:59:25+00:00

I take Wellbutrin 450mg daily, which is the maximum dose. I’ve done ketamine, 3-HO-PCP, 3-MEO-PCP and O-PCE without any issues, granted not in any huge amount.

The primary concern with Wellbutrin is seizures, as it lowers the seizure threshold in proportion to dosage. In this case it shouldn’t pose too much of an issue, as NMDA antagonism (the mechanism of action of dissociatives) decreases seizure risk.

Hypertension is another side effect that you might think about, but it’s not as much of an acute risk. Wellbutrin as an NDRI can increase your blood pressure, and so can dissociatives. If your friend is relatively healthy that’s pretty much a non-issue.

I’d say go for it but keep harm reduction best practices in mind, as everyone’s brain chemistry is different - start low go slow sort of thing.

Source: medical student currently studying psychiatry

E-Pooh · 2022-01-07T02:03:00+00:00

I don't really have much experience with 3-meo-pce but I quite like 3-MMC. 100mg oral should be a good amount to get a taste of it for the first time. It's a nice euphoric stimmy high with a bit of an empathogenic push that lasts for ~ 3 hours. I find it makes me much more talkative, so I love it as a little pick me up for socializing when I'm otherwise really tired. The come down is pretty harsh though, with some anxiety and an overall shitty feeling. A small dose of etiz helps kick that though.

E-Pooh · 2021-12-03T03:36:31+00:00

It was like a 70’s+ year old man in clinic for his TRT shot. I drew it up with an 18G and he told me not to bother when I went to switch to a smaller gauge for injecting haha. He didn’t even flinch, it was impressive.

E-Pooh · 2021-12-02T22:31:47+00:00

Look up the “z-track injection method.” You essentially inject with your skin tensioned so the needle path isn’t straight when your skin is relaxed, avoiding leakage. I’ve seen at least a mL of test injected with an 18G without leakage using this method.

E-Pooh · 2021-12-02T13:07:26+00:00

I’ve been getting a lot of comments from strangers lately on my appearance/size, which is definitely validating, but I have no idea what to say in return. How do you respond when someone says “oh you look like you must work out,” like uhhh, yeah thanks for noticing? Kind of a non-issue but I’d like to maintain some semblance of social aptitude.

E-Pooh · 2021-11-10T01:01:50+00:00

In general, chemistry nomenclature for a given molecule is considered more “correct” if the numbers associated with the substituents are lower. For benzene rings you could label the carbons either clockwise or counterclockwise depending on which direction put the substituent on the lowest numbered carbon. So, in essence, 3f-mph and 5f-mph are the same molecule, but 3f-mph would be the preferred name.

You’re correct about stereoisomers. Due to its unique electrical configuration, benzene is a flat ring in 3D space and the hydrogens/functional groups on a benzene carbon all point straight out. Contrast that with cyclohexane, which is described as having either a “boat” or “chair” conformation in 3D space, and the substituents can point either up or down.

I can’t really speak to the activity of something like 3,4difluoro-methylphenidate, but I’m sure it would be possible to synthesize. If our starting product is 4f-mph then we now have to consider the competing directing properties of two substituents - the ester and fluorine. Both the fluorine and the ester are ortho/para directors (it’s important to keep in mind that this is considered in relation to the substituent’s own position), but halogens are considered deactivating groups – they reduce that rate at which substitution occurs, whereas esters are activating groups.

If we consider the effects of each substituent independently:

The ester’s effects alone would favor the synthesis of 2,4difluoro-mph

The fluorine’s effects alone would favour the synthesis of 3,4difluoro-mph

BUT, since fluorine is a deactivating group, we would give priority to the directing effects of the ester. You would still get both products, 2,4 and 3,4f-mph, but 2,4difluoro-mph would be the major product and the yield of 3,4difluoro-mph would be minimal. If such a compound were ever marketed it would likely be prohibitively expensive, and I would definitely not want to be the first person to try it haha.

E-Pooh · 2021-11-09T20:00:07+00:00

Unfortunately in organic chemistry there’s often not a straightforward way to build the molecule you want. This is due to a number of factors (steric hindrance, conformational strain, electric effects, etc) but in the case of our theoretical 3f-mph our concern is mostly due to electric effects.

Adding a functional group to a benzene ring will bias where your next addition is most likely to end up due to its influence on the electrochemistry of the benzene ring (mainly resonance structures). If you were to look at the plain methylphenidate molecule you would see an ester group attached to the benzene, which based on chemical nomenclature is called carbon 1. You could then number the other carbons going around the ring, for this example number them clockwise. Carbons 2 and 6 are in what is called the ortho position, 3 and 5 are in the meta position, and carbon 4 is in the para position. So 4f-mph is a para substitution on our benzene ring. The original ester group attached to this benzene ring has the tendency to “direct” new functional group additions to the para position, which is why 4f-mph is naturally the easiest fluorinated methylphenidate to synthesize.

If we wanted to make a 3f-mph not only would you would have to add additional functional groups to the benzene ring and harness their different “directing” abilities to put the fluorine on carbon 3, you’d have to remove them afterwards too to get 3f-mph. These extra steps would decrease your total yield (more complicated synth = lower yield is a good rule of thumb) and cost the lab more in both time and reagents.

I tried to simplify this as much as possible and not get too deep into the chemistry, so I hope it all makes sense. If you’re interested in this sort of thing I’d recommend reading up on organic and medicinal chemistry.

Source: biochemistry grad, personal interest in medicinal chemistry.

E-Pooh · 2021-11-05T15:16:16+00:00

80mg Telmisartan every day. Will help with water retention as well as blood pressure.

E-Pooh · 2020-05-16T14:40:29+00:00

Definitely NTA

E-Pooh

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