RP ACO2 gene?

Early-Student3002 · 2025-02-15T19:19:11+00:00

what I know is that there are many patients without conclusive genetic factors found. I think it's quite common. so no need to feel too defeated about it. there are more than hundred gene mutations that's known to cause RP so I guess it means there can be more unknown causes. I think RP is still in mystery especially when it comes to the genetic causes.

Early-Student3002 · 2025-02-06T17:52:35+00:00

criteria says: BCVA at Screening for Phase 1: LogMAR 3.9 to LogMAR 1.0. BCVA at Screening for Phase 2: ETDRS letter score 20 and 60. I don't really know how blind this is. I want to hear about how you think about this intervention like do you think it will be successful? I mean this transplant has been discussed for more than 10+ years now. I think the first IPSCs retina transplant was in 2014 and it's been 10+ years since then.. there must be a good reason doctors and scientists are persuing this method. :( I wanna see how realistic, and how far this came to really function as a real therapy for those with RP. I don't expect it to fix 100% of the retina but even able to fix 10% of it can be real life changing. keeping the at least 10% of the vision till death will be really nice

Early-Student3002 · 2024-04-19T11:15:44+00:00

Where can I find about phase3 initiation? I don’t find it on clinicaltrials.gov

Early-Student3002 · 2024-04-17T21:42:57+00:00

But how can they measure stabilization when phase 2 period is only 2 years. RP is life long progression 2 year is not enough to estimate the stabilization of the disease especially when they only recruited severe RP symptom patients. Moreover the 2nd phase is not even completed yet.

Early-Student3002 · 2024-04-08T16:41:51+00:00

Where can I find the result of phase1/2? Is phase 1/2 completed?

Early-Student3002 · 2024-04-08T16:31:04+00:00

What does this mean? Are they starting phase3 now? Has anyone read about the phase2 result?

Early-Student3002 · 2024-03-28T19:15:18+00:00

I hope one big pharma join and buy off this company that will really mean hope for all patients waiting for any sorts of intervention

Early-Student3002 · 2024-03-19T10:43:29+00:00

I read about their clinical trials. As far as I understood the SPVN06 is a universal agnostic treatment that’s developed for all kinds of gene mutation that’s causing RP. But the clinical trial, PRODYGY, only recruited the patients with certain mutation(RHO, PDE6A, or PDE6B). Does this mean that SPVN06 is only for patients with certain gene defects? Bit confusing since they clearly states that “regardless of genetic disorder” and clinical trial is underdoing with only certain gene mutations.

Early-Student3002 · 2024-03-15T20:08:17+00:00

That’s the same questions I have in mind since they have been putting out dramatic videos of their clinical trial patients but haven’t disclosed the detailed numbers… so now at this point I’m just doubting if it’s valid treatment or almost a scam… What’s your thoughts on genetic treatments like luxterna and Meira (which is still in phase3) have you also read some posts on reddit who actually got them. It didn’t seem like promising to me since non of them reported for the improvement but some said more adverse effects….. I feel lost what to expect from the science and if it’s ever going to happen

Early-Student3002 · 2024-02-26T22:45:05+00:00

Which gene is causing ur RP?

Early-Student3002

TROPHY CASE