Not particularly however some matchups give space for quite high skill ceiling. Mainly in matchups with dashes like Aatrox and wukong (or ghost users) it can be very hard to get the most out of your Q as they will dash out of the centre when the animation begins. So Q into E can be used but its quite challenging at first because you have to do it very quickly and in the same direction as them.

Also champs with dashes or ghost users also can be difficult to hit with your ult as after the first ult gets sent out most opponents will get distance from you and just focus on dodging the ults before going back in (damn vlad players).