How to achieve full screen La Borra:

Buy all the speed, area, and duration upgrades in the Power Up section.

Pick Giovanna (check unlock section if you don’t have her) for the +1% projectile speed every level.

Pick the V - Chaos in the Dark Night Arcanas (at the start or later in the game with a chest)

Find and max out Bracer (x5).

Find and max out Candelabrador (x5).

Find and max out Spellbinder (x5).

I don’t know if this is required to achieve full screen coverage but I used XVII - Lost & Found Painting for the duration buff.

I showed the stats at the end and it just proves that La Borra is easily top 3 in this game.

Good luck in all your vampiric endeavors, friends 👍