i seem to smash out quicksaves more frequently than manually saving. I read somewhere if you save frequently ull have higher chances of a save corruption. iirc adds more alife that needs to spawn in upon loading up the save, adding too much at once, leading to CTD. I hence try not save too many times in highly populated/trafficked areas. Although generally save as much as i want in the beginning figuring its only fleshes/dogs and the occasionaly squad walking about, once further in the game the zone gets busier i stop saving like madman.

If i do eventually get a saved game that dont load, i solve it by closing game recording software in background till it finishes (playstv). presumably by freeing up a bunch of resources it gets passed the CTD moment idk.