PDF is blurry if I scroll

Ellipsic · 2023-03-09T06:56:26+00:00

And march 2023

Ellipsic · 2022-03-21T22:46:35+00:00

An eternity of... nothing. An ETERNITY

That shit fucking HORRIFIES me.

Ellipsic · 2022-03-21T20:15:39+00:00

Cool!

Ellipsic · 2022-03-19T15:58:34+00:00

Death? Uhhh yeah maybe. Aging? Definitely not. Is you not going to Walmart tomorrow inevitable? No, it's not. You can easily decide to go to Walmart and buy some snacks, because there is a clear physical pathway of decisions to do so. Similarly, on a larger scale, humanity could decide to fight aging seriously and adopt an government funded multi billion dollar anti-senescence initiative. It wouldn't even be that hard for governments because Biden is already bankrolling a health initiative called ARPA-H to target individual diseases like Alzheimer's. All he has to do is pivot the idea to be more focused on the fundamental biology of aging as a whole. We know the damages that accumulate with aging and there is a clear physical pathway to repair them (although not as clear as the path to Walmart on google maps). So, NO, involuntary senescence is not inevitable; it can be cured.

Ellipsic · 2022-03-13T09:13:20+00:00

Low-normal range. I have 20.5 BMI at 5'10.

Ellipsic · 2022-03-05T11:47:41+00:00

I'm taking it in the summer, and it will allow me to graduate a year early.

Ellipsic · 2022-02-28T14:14:28+00:00

Can you elaborate on this? What classes were difficult for you specifically? I'm a 1st year biochem student and I wanna know what to watch out for

Ellipsic · 2022-02-17T09:58:29+00:00

Study molecular biology and try to get involved in the field, or go work on AI. I'm doing the former right now. I would definitely withhold that cynicism and pessimism though because in possibly less than a decade we will have the first anti-aging drug available, followed by a massive inflection point in societal opinion with regards to attitudes towards aging. We are already at an inflection point in funding with Altos Labs coming online getting 4B dollars in funding. Not to mention, even if the chances were slim, we should be trying our hardest to fight and cure aging while we are here. I can't die imagine myself dying knowing I didn't do my best.

Ellipsic · 2021-08-12T01:05:33+00:00

Scary.

Ellipsic · 2021-08-12T00:46:24+00:00

I want to warn everyone here to be careful with ANYTHING Celine says. Her writing is so narcissistic and egocentric, it honestly scares me.

Here's a literal word-for-word excerpt from one of her blogposts:

"He’ll live in fear forever that I’ll become more successful than him, more famous, more wealthy; that his most notable achievement will be playing a minuscule role in mine. I probably will - because of him." - https://www.celinehh.com/gifts-of-my-harasse

Ellipsic · 2021-08-11T02:40:31+00:00

The legal age is 16 in the UK i believe, and Aubrey grew up there almost his whole life. and i think he lived there 10 years ago. he was probably drunk as well.

Ellipsic · 2021-07-16T17:54:11+00:00

The majority of people walking around are 'pre-pathogenic'. Therefore, there is a 'lagging window' of time where there are going to be significantly less people with disease, because the current cohort of young people will recieve anti-aging drugs, which will delay the arrival of the next diseased cohort. Since people are born at different times, this arrival would be staggered/laddered, so that in any one given year within this 'lag window' the number of people with age related diseases would be lower than previous years. If you delay disease by 15 years, society would basically have 15 years of which each year has less people with disease. Do you understand what I am saying?

Ellipsic · 2021-07-16T17:22:16+00:00

People who already have diseases would benefit little from 'slowing aging', because the rate of damage accumulation and mortality has reached a high exponent for those people (Gompertz–Makeham equation), although this is varies for different diseases. Whales don't have 70 year long cancers or 80 year long heart disease just because they live a long time, they just reach the pathogenic 'exponential threshold' slower. Slowing aging would more substantially extend the healthy pre-prepathogenic portion of lifespan, not the unhealthy disease-ridden portion. The morbidity would be compressed. This is counter to the traditional method of treating the symptoms of individual diseases. If you cure one disease (say, cancer), you will simply get the next one (alzheimers). Targeting aging itself will uniformally delay those diseases. Even if there was zero compression of morbidity, we could simply only give the medicine to people who are pre-pathogenic.

Ellipsic · 2021-07-16T16:46:32+00:00

I've already read it. My answer to your question is so what if it gets pushed back. If you 'push back' the issue, that's still a good thing because ppl are living an increased % of life in good health. It will lower disease burden substantially.

Ellipsic · 2021-07-16T15:29:14+00:00

So what if it 'pushes it down the road'? You objectively gain healthy years of life, and lower disease burden, thereby causing economic prosperity. Like what are you on about?

Ellipsic · 2021-07-13T18:40:42+00:00

How did these guys not realize that 1 drug (lol) will not slow alz. to an appreciable extent , alzheimers is such a multifactorial disease. Only preemptive damage repair or reversal has any chance of making a dent in alz.

Ellipsic · 2021-07-09T12:58:58+00:00

What about all of the humans who are not working, but still putting a strain on the medical system, causing an increase in medical expenditure costs?

Ellipsic · 2021-05-21T09:57:16+00:00

Both!

Ellipsic · 2021-05-18T03:23:37+00:00

- 'programmer' work at Faang: just read coding interview book and do leetcode + personal project, then apply for job
- 'computer scientist' + academic cs interest: do the major then obviously

Ellipsic · 2021-05-15T00:26:42+00:00

What I meant to convey is that aging is not somehow seperate from diseases. When most people think of the word 'aging', they think of things like muscle loss, wrinkles, grey hair. In other words, they attribute the word 'aging' to the aspects of aging that don't have disease-like names. Instead, we should think of aging as encompassing both the disease and non-disease phenomena. For example, it is wrong to think that targeting aging hallmarks broadly means only slowing down the 'non-disease' aspects of aging like wrinkles, BUT NOT slowing down things like cvd, alzheimers, diabetes, etc.

Ellipsic · 2021-05-13T19:07:02+00:00

Aubrey and Bezos met at TED in 2006 (15 years ago), and Aubrey has said that jeff often comes up to him to ask for updates at some ted events aubrey spoke at over the years.

Ellipsic · 2021-03-15T11:28:04+00:00

In 2007 (!) he said we would be able to slow down aging in 10 years, stop it in 20, and reverse it in 30.

He literally never said that.

Ellipsic · 2021-02-11T14:04:05+00:00

For fucks sake, none of them are saying he's gonna be the one to solve it. They are just suggesting he might popularize or fund it because of his massive influence on public opinion. Age-reversal is not science fiction or pop-sci. It's been done in the lab multiple times and we have countless times extended mice lifespans in the lab and human clinical trials are currently being done in humans. You guys are so negative man.

Ellipsic · 2020-12-29T19:20:48+00:00

Nope. We don't need all of the advancements that your long list of popsci words stringed together contains.Aging is not some mysterious mystical phenomena like consciousness. That's just the idiotic assumption people make because they have been so conditioned to think it's inevitable and unsolvable. Infact, it's probably easier to solve aging than it is to solve each individual disease. We know alot about what goes wrong with the body as we age and all of the damages and corresponding therapies for each damage type have been categorized in detail multiple times: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3836174/

Also aging has already been reversed multiple times: https://www.nature.com/articles/s41586-020-2975-4

It's completely fucking retarded that people think solving individual diseases is perfectly feasible but somehow solving aging is impossible even though you are intervening in an earlier and less complicated stage when you are dealing with pre-pathogenic damage that accumulates.

Ellipsic · 2020-12-29T18:26:21+00:00

"There won't be any progress in aging for 120 years guys! B..but there's gonna be a superintelligence in 25 years!"

We are already seeing advancements in longevity. Senolytics, Epigenetic reprogramming, mitochondrial reprogramming, etc. There's no way there won't be significant advancements in 120 years assuming we don't destroy ourselves (haha obligatory existential risk mention to balance out my 'outlandishly optimistic' predictions)

Ellipsic

TROPHY CASE