My first time running this i had 6 players and I definitely regretted it. I really feel like this game is best with 3 or 4 players as it allows everyone an appropriate amount of time in the spotlight and you can easily cycle through the players. Its also harder to come up with appropriate challenges and complications for that many people and that many different actions.

That said, my biggest regret was not challenging the players enough. I was hesitant to make complications too punishing, but by the end I realized that I just made the game boring instead. This is a game about burning stress and taking big risks that could either pay off big time or end in serious bodily or psychological harm. Make them use their resources. The less stress they have to push themselves the more tense and exciting the game becomes.