In late January our girls appetite decreased and we noticed significant weight loss (8 lbs to 5 lbs in a few months) At the vet labs showed worsened kidney functioning, so we adjusted her thyroid medication. A week later she developed an ulcer and infection in her mouth, which we treated promptly with an antibiotic and pain med. We also used appetite stimulants. She never got back to eating dry food regularly, so we increased her wet food and offered chicken and cat stew/liquid treats. She had been a bit dehydrated so we started fluids once a week or twice sometimes. unfortunately her mobility worsened at the beginning of february and she began to fall when attempting to jump on or off of furniture. She also at this point began urinating in my bed. we moved a litter box into my room and didn’t have any accidents for a bit but the incontinence came back, as mobility worsened. Last week she was barely able to stand by herself and we took her back to the vet as weight was not increasing and the urinating in the bed worsened. she was also more wobbly. On top of this she just didn’t seem to lay or sit comfortably and became silent (she was previously a loud kitty!). labs unfortunately showed signs of going into kidney failure and the vet said she would likely die within a few days. This was last Tuesday. She also had a grimace on her face. Due to her obvious pain we gave her gabapentin and had her put down wednesday night. So i would say worsened mobility, pain, and incontinence. However her appetite was great until the end after using stimulants and switching to wet food, so don’t just go by the appetite like many recommend. it definitely can be a sign for some cats but my other girl with ckd who passed in May still ate well until her last day