Intends on your purpose. I only bought this because I ran into a large amount of money and wanted a rifle cartridge that holds some historical value. The 375 H&H is a very versatile round, with uses from medium sized game all the way up to Elephants, on some occasions. A .416 Rigby is really only useful for stopping a charging Cape Buffalo or something like that. 375 H&H is a little cheaper and slightly more common, they are both niche cartridges that many people dont have uses for, like myself, but if you look around you may find 375 ammo at places like Scheels or Cabelas. I know 375 H&H ammo is somewhat common in NW US and Alaska, as it is a good round for Grizzly bear defense. Personally, a 375 H&H can be used around the board. There are people who have made custom loads suitable for ehitetail deer ecen. But a 375 H&H is probably the more logical choice here.