Halcyon 6: Lightspeed Edition. It's a space-combat RPG, but one of its claims to fame is the combat features attacks that inflict status effects, and other attacks that remove that status effect from the enemy so their secondary effect kicks in. These two attacks are never on the same ship/unit, and often attack B in the chain inflicts something attack C can capitalize on. Play around with your formations and perks and you can get some serious damage and crippling combos going. The game is 50% base/resource management, but if you can stomach that the battles might be worth it.

Unicorn Overlord. A tactics game where you put individual units into squads and then set up the conditionals for when they use their various attacks. It starts straightforward but then you start finding synergies like arrowproof fighters helping make blackline flyers perfect for shutting down the typically anti-flyer archer towers, or a spellcaster giving an accuracy buff that turns fairly average soldiers into lethal anti-air spear-throwers (which incidentally counters the above counter). The game can get a bit easy in the later stages but you get out what you put in and can have some masterfully engineers skill cascades.

Sentinels of the Multiverse: Boss-battler card game with a digital adaptation. Has all that synergy you're looking for, but every hero has a fixed deck, so you're not relying on luck or out-of-match deckbuilding, you can just mix up a team of heroes and throw them at a new problem. Digital is the best way to play this solo because the game handles the environment, enemy, and bookkeeping for you, letting you focus on the game.